Evidence map›Paper›PMID 27659931›Full record

Trial reportPeritoneal dialysis international : journal of the International Society for Peritoneal Dialysis

Effect of balance Solution on the Peritoneal Membrane in Automated Peritoneal Dialysis.

Tatiana De Los Ríos, Juan Pérez-Martínez, Jose Portoles, Monika Lichodziejewska-Niemierko, Maite Rivera, Michał Nowicki, Andrzej Książek, Ana María Tato, Christine Bohnhorst, Mariano Feriani

Abstract readClinical Trial, Phase IVMulticenter StudyRandomized Controlled Trial
In one paragraph

Trial report in Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Biocompatible dialysis fluids for peritoneal dialysis.The Cochrane database of systematic reviews · 2018
    Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Tatiana De Los RíosClinical Research, Fresenius Medical Care Deutschland GmbH, Bad Homburg, Germany tatiana.de-los-rios@fmc-ag.com.
Juan Pérez-MartínezNephrology, University Hospital of Albacete, Albacete, Spain.
Jose PortolesNephrology, Hospital Universitario Puerta de Hierro, Madrid, Spain.
Monika Lichodziejewska-NiemierkoNephrology, Centrum Dializ Fresenius Nephrocare, Gdansk, Poland.
Maite RiveraNephrology, Hospital Universitario Ramón y Cajal, Madrid, Spain.
Michał NowickiNephrology, Klinika Nefroloqii, Lodz, Poland.
Andrzej KsiążekNephrology, Klinika Nefroloqii, Lodz, Poland.
Ana María TatoNephrology, Hospital Universitario Fundación Alcorcón, Alcorcón, Spain.
Christine BohnhorstClinical Research, Fresenius Medical Care Deutschland GmbH, Bad Homburg, Germany.
Mariano FerianiDept. of Nephrology, Ospedale Umberto I, Rome, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Interference of conventional peritoneal dialysis fluids (cPDFs) with peritoneal membrane cell functions may be attributed to the dialysis fluid's low pH, high glucose concentration, and/or the presence of glucose degradation products (GDPs), the last of which leads to higher levels of advanced glycation end-products (AGEs). It has been suggested that the peritoneal membrane might be better preserved by using biocompatible solutions, including cancer antigetn 125 (CA125). This prospective, open-label, multicentre, randomized, controlled, cross-over phase IV study compared the in vivo biocompatibility of a neutral-pH, low-GDP peritoneal dialysis (PD) solution (balance) with a cPDF in automated PD (APD) patients. Our study revealed a significantly increased appearance rate and concentration of CA125 in the peritoneal effluent of APD patients treated with the neutral-pH, low-GDP solution balance versus a conventional PD solution.

Indexed as

AdultAutomationBicarbonatesBiocompatible MaterialsCA-125 AntigenConfidence IntervalsCreatinineCross-Over StudiesDialysis SolutionsFemaleGlucoseHumansHydrogen-Ion ConcentrationKidney Failure, ChronicMaleMiddle AgedBicarbonatesBiocompatible MaterialsCA-125 AntigenCreatinineDialysis SolutionsGlucoseUreaBiocompatibilitycancer antigen 125peritoneal dialysis fluidspH neutralresidual renal functionultrafiltration

Identifiers

PMID27659931
PMCPMC5033636

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.