ReviewChild's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery2016
Awake surgery for hemispheric low-grade gliomas: oncological, functional and methodological differences between pediatric and adult populations.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Reliability of intraoperative ultrasound in detecting tumor residual after brain diffuse glioma surgery: a systematic review and meta-analysis.Neurosurgical review · 2020Pooled it
- Awake Craniotomy for the Excision of a Pediatric Cerebral Arteriovenous Malformation for Language Preservation: A Case Description.Journal of personalized medicine · 2025Article
- Awake craniotomy in pediatric low-grade glioma: barriers and future directions.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2024Review
- Guidelines for Awake Surgery.Neurologia medico-chirurgica · 2024Article
- Passive functional mapping of receptive language cortex during general anesthesia using electrocorticography.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2023Article
- Structural networking of the developing brain: from maturation to neurosurgical implications.Frontiers in neuroanatomy · 2023Review
- The Use of Standardized Intraoperative Language Tests in Awake Craniotomies: A Scoping Review.Neuropsychology review · 2022Article
- Editorial: Awake surgery for brain tumors and brain connectomics.Frontiers in oncology · 2022Article
- The Exoscope in Neurosurgery: An Overview of the Current Literature of Intraoperative Use in Brain and Spine Surgery.Journal of clinical medicine · 2021Review
- Pediatric and Adult Low-Grade Gliomas: Where Do the Differences Lie?Children (Basel, Switzerland) · 2021Review
- Result of awake surgery for pediatric eloquent brain area tumors: single-center experience.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2020Article
- How many patients require brain mapping in an adult neuro-oncology service?Neurosurgical review · 2020Article
- Awake Craniotomy in a Child: Assessment of Eligibility with a Simulated Theatre Experience.Case reports in anesthesiology · 2020Article
- Awake brain surgery in children-review of the literature and state-of-the-art.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2019Review
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionBrain mapping through a direct cortical and subcortical electrical stimulation during an awake craniotomy has gained an increasing popularity as a powerful tool to prevent neurological deficit while increasing extent of resection of hemispheric diffuse low-grade gliomas in adults. However, few case reports or very limited series of awake surgery in children are currently available in the literature.
methodsIn this paper, we review the oncological and functional differences between pediatric and adult populations, and the methodological specificities that may limit the use of awake mapping in pediatric low-grade glioma surgery.
resultsThis could be explained by the fact that pediatric low-grade gliomas have a different epidemiology and biologic behavior in comparison to adults, with pilocytic astrocytomas (WHO grade I glioma) as the most frequent histotype, and with WHO grade II gliomas less prone to anaplastic transformation than their adult counterparts. In addition, aside from the issue of poor collaboration of younger children under 10 years of age, some anatomical and functional peculiarities of children developing brain (cortical and subcortical myelination, maturation of neural networks and of specialized cortical areas) can influence direct electrical stimulation methodology and sensitivity, limiting its use in children.
conclusionsTherefore, even though awake procedure with cortical and axonal stimulation mapping can be adapted in a specific subgroup of children with a diffuse glioma from the age of 10 years, only few pediatric patients are nonetheless candidates for awake brain surgery.
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