Evidence map›Paper›PMID 27659822›Full record

ReviewChild's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery2016

An integrative molecular and genomic analysis of pediatric hemispheric low-grade gliomas: an update.

Alvaro Lassaletta, Michal Zapotocky, Eric Bouffet, Cynthia Hawkins, Uri Tabori

Abstract readReview
PubMed Publisher
In one paragraph

Review in Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 36 citations in OpenAlex.

  1. Review
  2. Article
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  4. Review
  5. Article
  6. Future perspective of targeted treatments in pediatric low-grade glioma (pLGG): the evolution of standard-of-care and challenges of a new era.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2024
    Review
  7. Article
  8. Review
  9. Review
  10. Review
  11. Article
  12. Review
  13. Review
  14. International journal of molecular sciences · 2020
    Review
  15. Article
  16. Article
  17. A little piece of mind: best practices for brain tumor intraoperative consultation.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2019
    Review
  18. Article
  19. Article
  20. Molecular Basis of Pediatric Brain Tumors.Neuromolecular medicine · 2017
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Alvaro LassalettaDivision of Pediatric Neuro-oncology, The Hospital for Sick Children, University of Toronto, 555 University Avenue, Toronto, M5G 1X8, ON, Canada.ORCID http://orcid.org/0000-0003-2881-1473
Michal ZapotockyDivision of Pediatric Neuro-oncology, The Hospital for Sick Children, University of Toronto, 555 University Avenue, Toronto, M5G 1X8, ON, Canada.
Eric BouffetDivision of Pediatric Neuro-oncology, The Hospital for Sick Children, University of Toronto, 555 University Avenue, Toronto, M5G 1X8, ON, Canada.
Cynthia HawkinsDivision of Pathology, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.
Uri TaboriDivision of Pediatric Neuro-oncology, The Hospital for Sick Children, University of Toronto, 555 University Avenue, Toronto, M5G 1X8, ON, Canada. uri.tabori@sickkids.ca.
University of Toronto · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hemispheric low-grade gliomas account for the second most common location in pediatric low-grade gliomas (PLGGs) after the cerebellum. The pathological spectrum includes gangliogliomas, dysembryoplastic neuroepithelial tumors (DNETs), diffuse astrocytomas, pilocytic astrocytomas, and pleomorphic xanthoastrocytomas (PXAs), among others. Clinically, hemispheric PLGGs represent a well-recognized cause of intractable epilepsy in children and adolescents. With an excellent long-term outcome, surgery remains the cornerstone and patients with gross total resection typically do not need any further therapies. The recent literature about hemispheric PLGGs was reviewed to provide an up-to-date overview of the molecular and cell biology of these tumors. Hemispheric PLGGs can harbor multiple alterations involving BRAFV600E, FGFR, NTRK, MYB/MYBL1, IDH, and BRAF-KIAA1549 fusions. However, the clinical significance of most of these alterations is still to be defined. The role of RAS/MAPK mutations and other alterations in hemispheric PLGGs is of interest from diagnostic, prognostic, and therapeutic perspectives. Molecular testing for these tumors should be encouraged, since the findings can have an important impact not only in prognosis but also in therapeutic strategies.

Indexed as

AdolescentAnaplastic Lymphoma KinaseBrain NeoplasmsChildDNA-Binding ProteinsFemaleFunctional LateralityGenomicsGliomaHumansIsocitrate DehydrogenaseMaleMitogen-Activated Protein Kinase KinasesMutationNeurofibromin 1Nuclear ProteinsAnaplastic Lymphoma KinaseBRAF protein, humanDNA-Binding ProteinsFGFR1 protein, humanIsocitrate DehydrogenaseMitogen-Activated Protein Kinase KinasesMYBBP1A protein, humanNeurofibromin 1Nuclear ProteinsNucleocytoplasmic Transport ProteinsProto-Oncogene Proteins B-rafras ProteinsReceptor, Fibroblast Growth Factor, Type 1Receptor Protein-Tyrosine KinasesRNA-Binding ProteinsTranscription FactorsBRAFFGFRHemisphericLow-grade gliomasMYBPediatric

Identifiers

PMID27659822
OpenAlexW2522449181

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.