ArticleChild's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery2016
The relationship between transorbital ultrasound measurement of the optic nerve sheath diameter (ONSD) and invasively measured ICP in children. : Part II: age-related ONSD cut-off values and patency of the anterior fontanelle.
Article in Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 43 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Effect of Epidural Analgesia on Intracranial Pressure by Measuring the Optic Nerve Sheath Diameter Using Ultrasound in Pediatric Patients With Cerebral Palsy
The Effect of Continuous Epidural Analgesia on Intracranial Pressure by Measuring the Optic Nerve Sheath Diameter Using Ultrasound in Pediatric Patients
Who cites it
43 citing papers in PubMed, 1 synthesis or guideline pooled it.
- International evidence-based guidelines on Point of Care Ultrasound (POCUS) for critically ill neonates and children issued by the POCUS Working Group of the European Society of Paediatric and Neonatal Intensive Care (ESPNIC).Critical care (London, England) · 2020Guideline
- Evaluating the effect of caudal epidural block on optic nerve sheath diameter in pediatric patients: randomized controlled study.BMC anesthesiology · 2025Trial
- Ultrasonographic optic nerve sheath diameter for predicting elevated intracranial pressure and clinical severity in children: a prospective observational study.European journal of pediatrics · 2026Observational
- Comparison Between Ultrasound and Magnetic Resonance Imaging Measurements of the Optic Nerve Sheath Diameter in Patients Undergoing Intracranial Surgery: Prospective Observational Single-Center Study.JMIR perioperative medicine · 2026Observational
- Different injection speeds produce distinct temporal dynamics of optic nerve sheath diameter increase during caudal block in children: a prospective randomized trial.Frontiers in pediatrics · 2026Article
- Optic nerve sheath diameter trajectories and mortality in children with clinically relevant elevated intracranial pressure.World journal of critical care medicine · 2025Article
- Noninvasive Intracranial Pressure Prediction Using a Multimodal Ultrasound-Based Hemispheric Modeling Strategy: A Prospective Dual-Center Study.Neurocritical care · 2025Article
- Point of care ultrasound assessment of the optic nerve sheath diameter in critically ill children.BMC pediatrics · 2025Observational
- Effect of twin block on intracranial pressure.Clinical oral investigations · 2025Article
- Evaluation of near-infrared spectroscopy, transcranial Doppler, and ophthalmic ultrasound measurements in critically Ill pediatric patients with increased intracranial pressure.Frontiers in pediatrics · 2025Article
- Article
- Distinguishing Papilledema from Pseudopapilledema in Children.Advances in ophthalmology and optometry · 2024Article
- Ultrasound-guided initial diagnosis and follow-up of pediatric idiopathic intracranial hypertension.Pediatric radiology · 2024Article
- Transorbital point-of-care ultrasound versus fundoscopic papilledema to support treatment indication for potentially elevated intracranial pressure in children.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2024Article
- Changes in optic nerve sheath diameter and its correlation with degree of consciousness, pupil diameter, and light reflex in children with central nervous system infection after osmotherapy.Frontiers in pediatrics · 2024Article
- Influence of sex and disease etiology on the development of papilledema and optic nerve sheath extension in the setting of intracranial pressure elevation in children.Brain & spine · 2024Article
- Non-Invasive Quantitative Approximation of Intracranial Pressure in Pediatric Idiopathic Intracranial Hypertension Based on Point-of-Care Ultrasound of the Optic Nerve Sheath Diameter.Brain sciences · 2023Article
- Non-Invasive Intracranial Pressure Monitoring.Journal of clinical medicine · 2023Review
- A Narrative Review of Point of Care Ultrasound Assessment of the Optic Nerve in Emergency Medicine.Life (Basel, Switzerland) · 2023Review
- Neonatal and paediatric point-of-care ultrasound review.Australasian journal of ultrasound in medicine · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo analyse the diagnostic accuracy of age-related optic nerve sheath diameter (ONSD) cut-off values in children for detecting raised intracranial pressure (ICP) and to assess the benefit of using patency of the anterior fontanelle in describing a different set of cut-off values.
methodsThe ONSD measurement was performed prior to invasive ICP measurement in children under general anesthesia. The diagnostic accuracy of the ONSD measurement was compared to ICP at thresholds of 20, 15, 10, and 5 mmHg. This was further analysed in children above and below the age of 1 year, with a subgroup analysis of age at 4 years, and assessment of the anterior fontanelle (AF) as a reliable physiological marker in part II of this study.
resultsData from 174 children were analysed. In children ≤1 year old, the ONSD measurement with the best diagnostic accuracy for detecting ICP ≥ 20 mmHg was 5.16 mm, compared to 5.75 mm in children >1 year old (p < 0.001). In addition, patency of the anterior fontanelle (AF) was found to be a useful clinical marker for defining different ONSD cut-off values at ICP thresholds of 20, 15, 10 and 5 mmHg.
conclusionTransorbital ultrasound measurement of the ONSD is a reliable non-invasive marker of ICP particularly at higher thresholds of 20 and 15 mmHg. Patency of the AF is a useful clinical marker for defining different ONSD cut-off values in children.
Indexed as
Identifiers
27659820What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.