ArticleUltrasonic imaging2017
A Pilot Clinical Study in Characterization of Malignant Renal-cell Carcinoma Subtype with Contrast-enhanced Ultrasound.
Article in Ultrasonic imaging, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- Diagnostic Performance of Contrast-Enhanced Ultrasound in Renal Cancer: A Meta-Analysis.Frontiers in oncology · 2020Pooled it
- Contrast-enhanced ultrasound of renal collecting duct carcinoma: first report of quantitative microvascular characterization with pathologic correlation.Journal of ultrasound · 2026Article
- Diagnostic Value of Contrast-Enhanced Ultrasound in Differentiating Malignant from Benign Small Renal Masses After CT/MRI.Journal of clinical medicine · 2024Article
- Development and Characterization of Hemoglobin Microbubbles for Acoustic Blood Oxygen Level Dependent Imaging.ACS sensors · 2024Article
- Classifying Kidney Disease in a Vervet Model Using Spatially Encoded Contrast-Enhanced Ultrasound Perfusion Parameters.Ultrasound in medicine & biology · 2023Article
- Associations between tumor grade, contrast-enhanced ultrasound features, and microvascular density in patients with clear cell renal cell carcinoma: a retrospective study.Quantitative imaging in medicine and surgery · 2022Article
- Expanding the Role of Ultrasound for the Characterization of Renal Masses.Journal of clinical medicine · 2022Review
- The independent indicators for differentiating renal cell carcinoma from renal angiomyolipoma by contrast-enhanced ultrasound.BMC medical imaging · 2020Article
- CT texture analysis in the differentiation of major renal cell carcinoma subtypes and correlation with Fuhrman grade.European radiology · 2019Article
- Longitudinal characterization of local perfusion of the rat placenta using contrast-enhanced ultrasound imaging.Interface focus · 2019Article
- Histological and blood chemistry examination of the rodent kidney after exposure to flash-replenishment ultrasound contrast imaging.Ultrasonics · 2019Article
- Can contrast-enhanced ultrasound and acoustic radiation force impulse imaging characterize CT-indeterminate renal masses? A prospective evaluation with histological confirmation.World journal of urology · 2019Article
- Ultrasound Measurement of Vascular Density to Evaluate Response to Anti-Angiogenic Therapy in Renal Cell Carcinoma.IEEE transactions on bio-medical engineering · 2019Article
- Fast, Low-Frequency Plane-Wave Imaging for Ultrasound Contrast Imaging.Ultrasound in medicine & biology · 2018Article
- A new preclinical ultrasound platform for widefield 3D imaging of rodents.The Review of scientific instruments · 2018Article
- Ultrasound Molecular Imaging of VEGFR-2 in Clear-Cell Renal Cell Carcinoma Tracks Disease Response to Antiangiogenic and Notch-Inhibition Therapy.Theranostics · 2018Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Malignant renal cell carcinoma (RCC) is a diverse set of diseases, which are independently difficult to characterize using conventional MRI and CT protocols due to low temporal resolution to study perfusion characteristics. Because different disease subtypes have different prognoses and involve varying treatment regimens, the ability to determine RCC subtype non-invasively is a clinical need. Contrast-enhanced ultrasound (CEUS) has been assessed as a tool to characterize kidney lesions based on qualitative and quantitative assessment of perfusion patterns, and we hypothesize that this technique might help differentiate disease subtypes. Twelve patients with RCC confirmed pathologically were imaged using contrast-enhanced ultrasound. Time intensity curves were generated and analyzed quantitatively using 10 characteristic metrics. Results showed that peak intensity ( p = 0.001) and time-to-80% on wash-out ( p = 0.004) provided significant differences between clear cell, papillary, and chromophobe RCC subtypes. These results suggest that CEUS may be a feasible test for characterizing RCC subtypes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.