Evidence map›Paper›PMID 27659481›Full record

ArticleScientific reports2016

Expression of the aryl hydrocarbon receptor contributes to the establishment of intestinal microbial community structure in mice.

Iain A Murray, Robert G Nichols, Limin Zhang, Andrew D Patterson, Gary H Perdew

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed
4.5field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 88 citations in OpenAlex.

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  9. Pharmaceutical biology · 2024
    Review
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  19. Review
  20. Aryl Hydrocarbon Receptor (AhR) Activation by 2,3,7,8-Tetrachlorodibenzo-International journal of molecular sciences · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Iain A MurrayCenter for Molecular Toxicology &Carcinogenesis Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, PA-16802, USA.
Robert G NicholsCenter for Molecular Toxicology &Carcinogenesis Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, PA-16802, USA.
Limin ZhangCenter for Molecular Toxicology &Carcinogenesis Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, PA-16802, USA.
Andrew D PattersonCenter for Molecular Toxicology &Carcinogenesis Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, PA-16802, USA.
Gary H PerdewCenter for Molecular Toxicology &Carcinogenesis Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, PA-16802, USA.
Pennsylvania State University · US

Funding

REGULATION OF THE AH RECEPTORR01ES004869 · NIEHS · PURDUE UNIVERSITY WEST LAFAYETTE · PI PERDEW, GARY H. · 1994 to 2017
$5.3M
Optimized Metabolite Extraction, Separation, and Identification for MetabolomicsR01ES022186 · NIEHS · PENNSYLVANIA STATE UNIVERSITY, THE · PI PATTERSON, ANDREW · 2012 to 2016
$2.0M
Selective Ah Receptor Ligands Repress Acute-Phase ResponseR01ES019964 · NIEHS · PENNSYLVANIA STATE UNIVERSITY, THE · PI PERDEW, GARY H. · 2012 to 2016
$2.0M
NIEHS NIH HHS R01 ES004869NIEHS NIH HHS R01 ES019964NIEHS NIH HHS R01 ES022186
6 · The paper itself

Abstract

Environmental and genetic factors represent key components in the establishment/maintenance of the intestinal microbiota. The aryl hydrocarbon receptor (AHR) is emerging as a pleiotropic factor, modulating pathways beyond its established role as a xenobiotic sensor. The AHR is known to regulate immune surveillance within the intestine through retention of intraepithelial lymphocytes, functional redistribution of Th17/Treg balance. Consequently, environmental/genetic manipulation of AHR activity likely influences host-microbe homeostasis. Utilizing C57BL6/J Ahr

Identifiers

PMID27659481
PMCPMC5034278
OpenAlexW2521051629

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.