Evidence map›Paper›PMID 27659457›Full record

ArticleJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology2017

Prognostic significance of blood pressure response during vasodilator stress Rb-82 positron emission tomography myocardial perfusion imaging.

Bradley Witbrodt, Abhinav Goyal, Anita A Kelkar, Sharmila Dorbala, Benjamin J W Chow, Marcelo F Di Carli, Brent A Williams, Michael E Merhige, Daniel S Berman, Guido Germano and 6 more

Abstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Downward myocardial creep during stress PET imaging is inversely associated with mortality.European journal of nuclear medicine and molecular imaging · 2024
    Article
  2. Article
  3. Indirect evidence of sympathetic stimulation by regadenoson.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2019
    Article
  4. Article
  5. Review of cardiovascular imaging in the Journal of Nuclear Cardiology in 2017. Part 2 of 2: Myocardial perfusion imaging.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2018
    Review
  6. The blood pressure response to vasodilator stress does not provide independent prognostic information.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2017
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors.

Bradley WitbrodtDivision of Cardiology, Department of Medicine, Emory University School of Medicine, 1462 Clifton Rd., Room 503, Atlanta, GA, 30322, USA. bwitbro@emory.edu.
Abhinav GoyalDivision of Cardiology, Department of Medicine, Emory University School of Medicine, 1462 Clifton Rd., Room 503, Atlanta, GA, 30322, USA.
Anita A KelkarDivision of Cardiology, Department of Medicine, Emory University School of Medicine, 1462 Clifton Rd., Room 503, Atlanta, GA, 30322, USA.
Sharmila DorbalaBrigham and Women's Hospital, Boston, MA, USA.
Benjamin J W ChowDepartment of Medicine, University of Ottawa Heart Institute, Ottawa, ON, USA.
Marcelo F Di CarliBrigham and Women's Hospital, Boston, MA, USA.
Brent A WilliamsGeisinger Medical Center, Danville, PA, USA.
Michael E MerhigeNiagara Falls Memorial Medical Center, Buffalo, NY, USA.
Daniel S BermanCedars-Sinai Medical Center, Los Angeles, CA, USA.
Guido GermanoCedars-Sinai Medical Center, Los Angeles, CA, USA.
Robert S BeanlandsDepartment of Medicine, University of Ottawa Heart Institute, Ottawa, ON, USA.
James K MinWeill Cornell Medical College New York, New York, NY, USA.
Punitha ArasaratnamDepartment of Medicine, University of Ottawa Heart Institute, Ottawa, ON, USA.
Masoud SadreddiniDepartment of Medicine, University of Ottawa Heart Institute, Ottawa, ON, USA.
Marjolein Lidwine van VelthuijsenDepartment of Medicine, University of Ottawa Heart Institute, Ottawa, ON, USA.
Leslee J ShawDivision of Cardiology, Department of Medicine, Emory University School of Medicine, 1462 Clifton Rd., Room 503, Atlanta, GA, 30322, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundA drop in blood pressure (BP) or blunted BP response is an established high-risk marker during exercise myocardial perfusion imaging (MPI); however, data are sparse regarding the prognostic value of BP response in patients undergoing vasodilator stress rubidium-82 (Rb-82) Positron Emission Tomography (PET) MPI. METHODS AND

resultsFrom the PET Prognosis Multicenter Registry, a cohort of 3413 patients underwent vasodilator stress Rb-82 PET MPI with dipyridamole or adenosine. We used multivariable Cox proportional hazard regression to analyze the association with mortality of four BP variables: stress minus rest systolic BP (∆SBP), stress minus rest diastolic BP (∆DBP), resting systolic BP (rSBP), and resting diastolic BP (rDBP). Covariates that had univariate P values <.10 were entered into the multivariable model. After median 1.7 years follow-up, 270 patients died. In univariate analyses, ∆SBP (P = .082), rSBP (P = .008), and rDBP (P < .001) were of potential prognostic value (P < .10), but ∆DBP was not (P = .96). After adjustment for other clinical and MPI variables, ∆SBP no longer independently predicted mortality (P = .082); only lower rSBP (P = .026) and lower rDBP (P = .045) remained independently prognostic.

conclusionsIn patients undergoing vasodilator stress MPI, only lower resting BP is an independent predictor of mortality along with other clinical and MPI variables; BP response does not appear to add to risk stratification in these patients.

Indexed as

Rubidium RadioisotopesAgedAged, 80 and overBlood PressureFemaleHumansMaleMiddle AgedMyocardial Perfusion ImagingPositron-Emission TomographyPrognosisProportional Hazards ModelsRegistriesVasodilator AgentsRubidium RadioisotopesVasodilator AgentsBlood pressure responsemyocardial perfusion imaging (MPI)positron emission tomography (PET)prognosisvasodilator stress

Identifiers

PMID27659457

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.