Evidence map›Paper›PMID 27659423›Full record

ArticleAmerican journal of physiology. Gastrointestinal and liver physiology2016

A novel transgenic mouse model of lysosomal storage disorder.

Sonia Ortiz-Miranda, Rui Ji, Agata Jurczyk, Ken-Edwin Aryee, Shunyan Mo, Terry Fletcher, Scott A Shaffer, Dale L Greiner, Rita Bortell, Ronald G Gregg and 3 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Gastrointestinal and liver physiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact, top 88% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 1 country.

Sonia Ortiz-MirandaCummings School of Veterinary Medicine, Tufts University, Grafton, Massachusetts.
Rui JiDepartments of Biochemistry & Molecular Genetics and Ophthalmology & Visual Science, University of Louisville, Louisville, Kentucky.
Agata JurczykDiabetes Center of Excellence, University of Massachusetts Medical School, Worcester, Massachusetts.
Ken-Edwin AryeeDiabetes Center of Excellence, University of Massachusetts Medical School, Worcester, Massachusetts.
Shunyan MoDepartment of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts.
Terry FletcherDepartments of Pharmacology & Toxicology and Pathology, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas.
Scott A ShafferDepartment of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts.
Dale L GreinerDiabetes Center of Excellence, University of Massachusetts Medical School, Worcester, Massachusetts.
Rita BortellDiabetes Center of Excellence, University of Massachusetts Medical School, Worcester, Massachusetts.
Ronald G GreggDepartments of Biochemistry & Molecular Genetics and Ophthalmology & Visual Science, University of Louisville, Louisville, Kentucky.
Alan ChengDepartments of Biochemistry & Molecular Genetics and Ophthalmology & Visual Science, University of Louisville, Louisville, Kentucky.
Leah J HenningsDepartments of Pharmacology & Toxicology and Pathology, College of Medicine, University of Arkansas for Medical Sciences, Little Rock, Arkansas.
Ann R RittenhouseDepartment of Microbiology & Physiological Systems, University of Massachusetts Medical School, Worcester, Massachusetts; ann.rittenhouse@umassmed.edu.ORCID 0000-0002-7446-230X
University of Massachusetts Chan Medical School · USUniversity of Louisville · USUniversity of Arkansas for Medical Sciences · USTufts University · US

Funding

Arkansas Center for Clinical and Translational ResearchUL1TR000039 · NCATS · UNIV OF ARKANSAS FOR MED SCIS · PI BECK, CORNELIA MARIE, JAMES, LAURA P · 2012 to 2014
$10.0M
Development and Validation of Novel NSG Mouse Models for Human Stem Cell TherapyR24OD018259 · OD · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI BREHM, MICHAEL ALLEN, GREINER, DALE LESLIE · 2014 to 2017
$3.0M
Depolarization-secretion couplingR01NS093384 · NINDS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI ORTIZ-MIRANDA, SONIA · 2016 to 2018
$1.1M
Transmission Electron Microscope for Core EM FacilityS10RR027897 · NCRR · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI CRAIG, ROGER W · 2009 to 2009
$500k
NCATS NIH HHS UL1 TR000039NCRR NIH HHS S10 RR027897NIH HHS R24 OD018259NINDS NIH HHS R01 NS093384
6 · The paper itself

Abstract

Knockout technology has proven useful for delineating functional roles of specific genes. Here we describe and provide an explanation for striking pathology that occurs in a subset of genetically engineered mice expressing a rat Ca

Indexed as

AnimalsCalcium Channels, L-TypeCholesterolDisease Models, AnimalHepatocytesLiverLysosomal Storage DiseasesLysosomesMacrophagesMiceMice, TransgenicPromoter Regions, GeneticSpleenTriglyceridesCacnb2 protein, mouseCalcium Channels, L-TypeCholesterolTriglyceridesCACNB2lincRNAlysosomal storage disordersmiRNATNF Receptor Superfamily Member 6

Identifiers

PMID27659423
PMCPMC5130545
OpenAlexW2523739680

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.