ArticleScientific reports2016
High Fructose Diet inducing diabetes rapidly impacts olfactory epithelium and behavior in mice.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 29 citations in OpenAlex.
- High-Intensity Interval Training Ameliorates High-Fat Diet-Induced Cognitive Impairment and Is Associated with Altered Adipokine Signaling in the Olfactory Bulb and Hippocampus.Molecular neurobiology · 2026Article
- Olfactory dysfunction in obesity and type 2 diabetes: mechanistic insights from preclinical models.Diabetologia · 2026Review
- Models of hyperglycaemia in diabetes mellitus and its complications.Nature reviews. Endocrinology · 2026Review
- Up regulated hippocampal insulin pathway and oxidative stress are related to opposite changes in olfaction and episodic memory in a compensatory metabolic syndrome model in rats.Frontiers in cellular neuroscience · 2026Article
- Interleukin-1β depresses neuronal activity in the rat olfactory bulb even during odor stimulation.PloS one · 2025Article
- Impact of Nutritional Status on COVID-19-Induced Olfactory Dysfunction.The Laryngoscope · 2024Article
- Activation of Granulocytes in Response to a High Protein Diet Leads to the Formation of Necrotic Lesions in the Liver.Metabolites · 2023Article
- Regulation of Metabolic Health by an "Olfactory-Hypothalamic Axis" and Its Possible Implications for the Development of Therapeutic Approaches for Obesity and T2D.Cellular and molecular neurobiology · 2022Review
- Consumption of dietary fat causes loss of olfactory sensory neurons and associated circuitry that is not mitigated by voluntary exercise in mice.The Journal of physiology · 2022Article
- Western Diet Accelerates the Impairment of Odor-Related Learning and Olfactory Memory in the Mouse.ACS chemical neuroscience · 2020Article
- Olfactory Dysfunction in Diabetic Rats is Associated with miR-146a Overexpression and Inflammation.Neurochemical research · 2020Article
- Perinatal exposure to diets with different n-6:n-3 fatty acid ratios affects olfactory tissue fatty acid composition.Scientific reports · 2020Article
- Review
- Reduced Olfactory Bulb Volume in Obesity and Its Relation to Metabolic Health Status.Frontiers in human neuroscience · 2020Article
- Article
- Type 2 diabetes impairs odour detection, olfactory memory and olfactory neuroplasticity; effects partly reversed by the DPP-4 inhibitor Linagliptin.Acta neuropathologica communications · 2018Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Type 2 Diabetes (T2D), a major public health issue reaching worldwide epidemic, has been correlated with lower olfactory abilities in humans. As olfaction represents a major component of feeding behavior, its alteration may have drastic consequences on feeding behaviors that may in turn aggravates T2D. In order to decipher the impact of T2D on the olfactory epithelium, we fed mice with a high fructose diet (HFruD) inducing early diabetic state in 4 to 8 weeks. After only 4 weeks of this diet, mice exhibited a dramatic decrease in olfactory behavioral capacities. Consistently, this decline in olfactory behavior was correlated to decreased electrophysiological responses of olfactory neurons recorded as a population and individually. Our results demonstrate that, in rodents, olfaction is modified by HFruD-induced diabetes. Functional, anatomical and behavioral changes occurred in the olfactory system at a very early stage of the disease.
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Registered trials
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