ArticleGenome biology2016
The whole genome sequence of the Mediterranean fruit fly, Ceratitis capitata (Wiedemann), reveals insights into the biology and adaptive evolution of a highly invasive pest species.
Article in Genome biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 76 papers, 1 of them a synthesis that pooled it.
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Who cites it
76 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Genomic investigations of successful invasions: the picture emerging from recent studies.Biological reviews of the Cambridge Philosophical Society · 2025Pooled it
- Chromosome-scale genome assembly of the South American fruit fly, Anastrepha fraterculus sp.1.Insect science · 2026Article
- Functional validation of a white pupae minimal gene construct in Ceratitis capitata (Diptera: Tephritidae).Insect science · 2026Article
- Sequence and expression analysis of potential spermatogenesis-specific gene cognates in the Caribbean fruit fly, Anastrepha suspensa.Insect science · 2026Article
- CiFi: accurate long-read chromosome conformation capture with low-input requirements.Nature communications · 2025Article
- Telomere-to-telomere genome assembly of the Dipteran Bactrocera dorsalis from a single individual.Nature communications · 2025Article
- Odorant-binding proteins (OBPs) in Ceratitis capitata Wiedemann (Diptera: Tephritidae): integrative analysis of a multigene family.Journal of insect science (Online) · 2025Article
- Functional Annotation and Comparative Analysis of Cytochrome P450 Protein Family Genes in Nine Chironomidae Species.Biology · 2025Article
- Decoding and engineering temperature-sensitive lethality inProceedings of the National Academy of Sciences of the United States of America · 2025Article
- The immune response of Phytoseiulus persimilis (Acari: Phytoseiidae) to the bacterial pathogen Acaricomes phytoseiuli.Experimental & applied acarology · 2025Article
- Gut bacteria facilitate leaf beetles in adapting to dietary specialization by enhancing larval fitness.NPJ biofilms and microbiomes · 2024Article
- Chromosome-scale genome of the polyphagous pest Anastrepha ludens (Diptera: Tephritidae) provides insights on sex chromosome evolution in Anastrepha.G3 (Bethesda, Md.) · 2024Article
- Divergent Heat Stress Responses inInsects · 2024Article
- Article
- A two-level staging system for the embryonic morphogenesis of the Mediterranean fruit fly (medfly) Ceratitis capitata.PloS one · 2024Article
- A new genome sequence resource for five invasive fruit flies of agricultural concern:F1000Research · 2024Article
- Immunodetection of Truncated Forms of the α6 Subunit of the nAChR in the Brain of Spinosad ResistantInsects · 2023Article
- Chromosome-level genome assembly of an important wolfberry fruit fly (Neoceratitis asiatica Becker).Scientific data · 2023Article
- Phylogenomic analysis provides diagnostic tools for the identification ofEvolutionary applications · 2023Article
- Genomic and cytogenetic analysis of the Ceratitis capitata temperature-sensitive lethal region.G3 (Bethesda, Md.) · 2023Article
16 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
65 authors.
Funding
Abstract
backgroundThe Mediterranean fruit fly (medfly), Ceratitis capitata, is a major destructive insect pest due to its broad host range, which includes hundreds of fruits and vegetables. It exhibits a unique ability to invade and adapt to ecological niches throughout tropical and subtropical regions of the world, though medfly infestations have been prevented and controlled by the sterile insect technique (SIT) as part of integrated pest management programs (IPMs). The genetic analysis and manipulation of medfly has been subject to intensive study in an effort to improve SIT efficacy and other aspects of IPM control.
resultsThe 479 Mb medfly genome is sequenced from adult flies from lines inbred for 20 generations. A high-quality assembly is achieved having a contig N50 of 45.7 kb and scaffold N50 of 4.06 Mb. In-depth curation of more than 1800 messenger RNAs shows specific gene expansions that can be related to invasiveness and host adaptation, including gene families for chemoreception, toxin and insecticide metabolism, cuticle proteins, opsins, and aquaporins. We identify genes relevant to IPM control, including those required to improve SIT.
conclusionsThe medfly genome sequence provides critical insights into the biology of one of the most serious and widespread agricultural pests. This knowledge should significantly advance the means of controlling the size and invasive potential of medfly populations. Its close relationship to Drosophila, and other insect species important to agriculture and human health, will further comparative functional and structural studies of insect genomes that should broaden our understanding of gene family evolution.
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