ArticleScientific reports2016
Stereological analyses of the whole human pancreas.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed.
- Integrated histopathology of the human pancreas throughout stages of type 1 diabetes progression.Nature communications · 2026Article
- Defining the islet: a minimum size threshold and opportunities for standardization.Frontiers in endocrinology · 2026Review
- Integrated histopathology of the human pancreas throughout stages of type 1 diabetes progression.bioRxiv : the preprint server for biology · 2025Article
- Could Pancreatic Islet Transplantation Outcome Be Impacted by Overestimating Islet Volume? Insights From a Serial Section Study.Journal of diabetes research · 2025Article
- Leveraging pre-trained machine learning models for islet quantification in type 1 diabetes.Journal of pathology informatics · 2025Article
- Article
- Interaction of serotonin/GLP-1 circuitry in a dual preclinical model for psychiatric disorders and metabolic dysfunction.Psychiatry research · 2024Article
- Article
- Ferroptosis in pancreatic diseases: potential opportunities and challenges that require attention.Human cell · 2023Review
- Pancreatic β-cell heterogeneity in adult human islets and stem cell-derived islets.Cellular and molecular life sciences : CMLS · 2023Review
- The Human Islet: Mini-Organ With Mega-Impact.Endocrine reviews · 2021Review
- Dynamin deficiency causes insulin secretion failure and hyperglycemia.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- State-of-the-art microscopy to understand islets of Langerhans: what to expect next?Immunology and cell biology · 2021Review
- Islet sympathetic innervation and islet neuropathology in patients with type 1 diabetes.Scientific reports · 2021Article
- Pancreas Optical Clearing and 3-D Microscopy in Health and Diabetes.Frontiers in endocrinology · 2021Review
- Whole-Slide Image Analysis of Human Pancreas Samples to Elucidate the Immunopathogenesis of Type 1 Diabetes Using the QuPath Software.Frontiers in molecular biosciences · 2021Article
- Inadequate β-cell mass is essential for the pathogenesis of type 2 diabetes.The lancet. Diabetes & endocrinology · 2020Review
- Developmental exposure to the endocrine disruptor tolylfluanid induces sex-specific later-life metabolic dysfunction.Reproductive toxicology (Elmsford, N.Y.) · 2019Article
- Heterogeneity of the Human Pancreatic Islet.Diabetes · 2019Article
- Three Dimensional Glomerular Reconstruction: A Novel Approach to Evaluate Renal Microanatomy in Diabetic Kidney Disease.Scientific reports · 2019Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
The large size of human tissues requires a practical stereological approach to perform a comprehensive analysis of the whole organ. We have developed a method to quantitatively analyze the whole human pancreas, as one of the challenging organs to study, in which endocrine cells form various sizes of islets that are scattered unevenly throughout the exocrine pancreas. Furthermore, the human pancreas possesses intrinsic characteristics of intra-individual variability, i.e. regional differences in endocrine cell/islet distribution, and marked inter-individual heterogeneity regardless of age, sex and disease conditions including obesity and diabetes. The method is built based on large-scale image capture, computer-assisted unbiased image analysis and quantification, and further mathematical analyses, using widely-used software such as Fiji/ImageJ and MATLAB. The present study includes detailed protocols of every procedure as well as all the custom-written computer scripts, which can be modified according to specific experimental plans and specimens of interest.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.