ArticleScientific reports2016
Gut microbiota Modulated by Probiotics and Garcinia cambogia Extract Correlate with Weight Gain and Adipocyte Sizes in High Fat-Fed Mice.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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The trial behind it
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Who cites it
25 citing papers in PubMed, 53 citations in OpenAlex.
- Effects of Konjaku Flour on the Gut Microbiota of Obese Patients.Frontiers in cellular and infection microbiology · 2022Trial
- The Effects of Synbiotic Supplementation on Metabolic Status in Diabetic Patients Undergoing Hemodialysis: a Randomized, Double-Blinded, Placebo-Controlled Trial.Probiotics and antimicrobial proteins · 2019Trial
- Synergistic Anti-Obesity Effect ofFood science & nutrition · 2026Article
- Isolation, Characterization and Probiotic Properties ofIndian journal of microbiology · 2025Article
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- Combination ofNutrients · 2023Article
- Altered gut microbiota in older adults with mild cognitive impairment: a case-control study.Frontiers in aging neuroscience · 2023Article
- Potential novel biomarkers in small intestine for obesity/obesity resistance revealed by multi-omics analysis.Lipids in health and disease · 2022Article
- Recent Advances inACS omega · 2022Review
- NovelInternational journal of molecular sciences · 2022Article
- Differential effects ofFrontiers in endocrinology · 2022Article
- A multi-strain probiotic blend reshaped obesity-related gut dysbiosis and improved lipid metabolism in obese children.Frontiers in nutrition · 2022Article
- The role of the gut microbiome in cancer-related fatigue: pilot study on epigenetic mechanisms.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2021Article
- Review
- Article
- The aging mouse microbiome has obesogenic characteristics.Genome medicine · 2020Article
- Lactobacillus plantarum FRT10 alleviated high-fat diet-induced obesity in mice through regulating the PPARα signal pathway and gut microbiota.Applied microbiology and biotechnology · 2020Article
- Establishment and evaluation of prediction model for multiple disease classification based on gut microbial data.Scientific reports · 2019Article
- Effect of the combined action ofVeterinary world · 2018Article
- Rhizosphere microbiome structure alters to enable wilt resistance in tomato.Nature biotechnology · 2018Article
Corrections and comments
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Authors and funding
12 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Results of recent studies on gut microbiota have suggested that obesogenic bacteria exacerbate obesity and metabolic dysfunction in the host when fed a high fat diet (HFD). In order to explore obesity-associated bacterial candidates and their response to diet, the composition of faecal bacterial communities was investigated by analyzing 16S rRNA gene sequences in mice. Dietary intervention with probiotics and Garcinia cambogia extract attenuated weight gain and adipocyte size in HFD-fed mice. To identify obesity-causative microbiota, two statistical analyses were performed. Forty-eight bacterial species were found to overlap between the two analyses, indicating the commonly identified species as diet-driven and obesity-associated, which would make them strong candidates for host-microbiome interaction on obesity. Finally, correlation based network analysis between diet, microbe, and host revealed that Clostridium aminophilum, a hyper-ammonia-producing bacterium, was highly correlated with obesity phenotypes and other associated bacteria, and shown to be suppressed by the combination of probiotics and Garcinia cambogia extract. Results of the present study suggest that probiotics and Garcinia cambogia extract alleviate weight gain and adiposity, in part via differentially modulating the composition of gut microbiota in HFD fed mice.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.