Evidence map›Paper›PMID 27658681›Full record

ArticleInternational ophthalmology2017

Clinical characterization of posterior polymorphous corneal dystrophy in patients of Indian ethnicity.

Sunita Chaurasia, Rashmi Mittal, G Bichappa, Muralidhar Ramappa, Somasheila I Murthy

Abstract read
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In one paragraph

Article in International ophthalmology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.3field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Update on the genetics of corneal endothelial dystrophies.Indian journal of ophthalmology · 2022
    Review
  3. Specular microscopy in clinical practice.Indian journal of ophthalmology · 2021
    Review
  4. Corneal dystrophies.Nature reviews. Disease primers · 2020
    Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Sunita ChaurasiaTej Kohli Cornea Institute, LV Prasad Eye Institute, Kallam Anji Reddy Campus, Banjara Hills, Hyderabad, 560 034, India. sunita@lvpei.org.
Rashmi MittalTej Kohli Cornea Institute, LV Prasad Eye Institute, Kallam Anji Reddy Campus, Banjara Hills, Hyderabad, 560 034, India.
G BichappaTej Kohli Cornea Institute, LV Prasad Eye Institute, Kallam Anji Reddy Campus, Banjara Hills, Hyderabad, 560 034, India.
Muralidhar RamappaTej Kohli Cornea Institute, LV Prasad Eye Institute, Kallam Anji Reddy Campus, Banjara Hills, Hyderabad, 560 034, India.
Somasheila I MurthyTej Kohli Cornea Institute, LV Prasad Eye Institute, Kallam Anji Reddy Campus, Banjara Hills, Hyderabad, 560 034, India.
L V Prasad Eye Institute · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo characterize the clinical presentation of posterior polymorphous corneal dystrophy (PPCD) in eyes of Indian ethnicity.

designRetrospective cohort study from January 1995 to December 2015.

participantsPatients with the diagnosis of posterior polymorphous corneal dystrophy.

methodsMedical records of the patients were reviewed for clinical presentation. Histology of corneal specimens of those that underwent keratoplasty was assessed.

main outcome measuresDescriptive analysis of clinical condition.

resultsMean age at first evaluation was 32.5 years (range 1-73 years), male:female = 35:18. Majority (44/53; 83 %) of the patients had bilateral involvement. 5/9 (44 %) patients with unilateral presentation were amblyopic in the affected eye. The clinical features documented were vesicles in 94 eyes, band-like pattern in 32 eyes, edema of varying degree in 23 eyes (12 patients, 1 patient was one eyed), and anterior segment changes in 1 eye. 8/45 (17 %) eyes had a regular astigmatism with steep axis >47 D (range 47.2-56.2 D). 16 eyes of 12 patients who had clinically evident corneal edema underwent keratoplasty. Mean age at keratoplasty was 58 years (range 1-73 years). 8 patients had penetrating keratoplasty (PK) and 8 had Descemet stripping endothelial keratoplasty (DSEK). Mean follow-up after keratoplasty was 4.2 years (1 month to 13 years). Except one, all grafts remained clear till the last follow-up. In all specimens, the Descemet membrane was grossly thickened.

conclusionsIn our study, 12/53 (22.6 %) patients required keratoplasty for visually significant corneal edema. Except one, all were older adults. The patients who needed keratoplasty were bilaterally afflicted and had visually significant cornea edema in both eyes. With a mean follow-up duration of 4.2 years after keratoplasty, no recurrences were noted.

Indexed as

EthnicityAdolescentAdultAgedChildChild, PreschoolCorneaCorneal Dystrophies, HereditaryCorneal TopographyFemaleFollow-Up StudiesHumansIndiaInfantKeratoplasty, PenetratingMaleCorneal endotheliumDescemet membraneDystrophyKeratoplastyPosterior polymorphous endothelial dystrophy

Identifiers

PMID27658681
OpenAlexW2521147421

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.