ArticleThe Korean journal of parasitology2016
Antiplasmodial and Cytotoxic Activities of Toad Venoms from Southern Amazon, Brazil.
Article in The Korean journal of parasitology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 28 citations in OpenAlex.
- From Chemical Defense to Drug Discovery: Bioactive Molecules, Pharmacological Activities, and Therapeutic Potential ofBiology · 2026Review
- Development and validation of a spectrophotometric method for the quantification of total bufadienolides in samples of toad glandular secretions.The journal of venomous animals and toxins including tropical diseases · 2025Article
- Antimalarial efficacy ofJournal of parasitic diseases : official organ of the Indian Society for Parasitology · 2024Article
- Identifying toxic effects and metabolic perturbations ofToxicology research · 2024Article
- New Insights on the Role of Marinobufagenin from Bench to Bedside in Cardiovascular and Kidney Diseases.International journal of molecular sciences · 2023Review
- Toxins from Animal Venoms as a Potential Source of Antimalarials: A Comprehensive Review.Toxins · 2023Review
- Uncovering the antimalarial potential of toad venoms through a bioassay-guided fractionation process.International journal for parasitology. Drugs and drug resistance · 2022Article
- Vasoconstrictor and hemodynamic effects of a methanolic extract from Rhinella marina toad poison.Toxicon : official journal of the International Society on Toxinology · 2022Article
- Animal Venom for Medical Usage in Pharmacopuncture in Korean Medicine: Current Status and Clinical Implication.Toxins · 2021Review
- Dehydrobufotenin extracted from the Amazonian toadThe journal of venomous animals and toxins including tropical diseases · 2021Article
- Antimicrobial Secretions of Toads (Anura, Bufonidae): Bioactive Extracts and Isolated Compounds against Human Pathogens.Antibiotics (Basel, Switzerland) · 2020Review
- Article
- Biochemical and Biological Profile of Parotoid Secretion of the AmazonianBioMed research international · 2019Article
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The drug-resistance of malaria parasites is the main problem in the disease control. The huge Brazilian biodiversity promotes the search for new compounds, where the animal kingdom is proving to be a promising source of bioactive compounds. The main objective of this study was to evaluate the antiplasmodial and cytotoxic activity of the compounds obtained from the toad venoms of Brazilian Amazon. Toad venoms were collected from the secretion of Rhinella marina and Rhaebo guttatus in Mato Grosso State, Brazil. The powder was extracted at room temperature, yielding 2 extracts (RG and RM) and a substance ('1') identified as a bufadienolide, named telocinobufagin. Growth inhibition, intraerythrocytic development, and parasite morphology were evaluated in culture by microscopic observations of Giemsa-stained thin blood films. Cytotoxicity was determined against HepG2 and BGM cells by MTT and neutral red assays. The 2 extracts and the pure substance ('1') tested were active against chloroquine-resistant Plasmodium falciparum strain, demonstrating lower IC50 values. In cytotoxic tests, the 2 extracts and substance '1' showed pronounced lethal effects on chloroquine-resistant P. faciparum strain and low cytotoxic effect, highlighting toad parotoid gland secretions as a promising source of novel lead antiplasmodial compounds.
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