ArticleScientific reports2016
Transmembrane Helices Tilt, Bend, Slide, Torque, and Unwind between Functional States of Rhodopsin.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Mapping signal transduction in bistable jumping spider rhodopsin 1.Biophysical journal · 2026Article
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- Chirobiophore: A Novel Framework for Quantifying Biochirality in Macromolecular Systems.Biomolecules · 2026Article
- Identification and characterization of 13 gene families encoding enzymes involved in flavonoid biosynthesis in barley and their roles under abiotic stress.Scientific reports · 2026Article
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- Improving AlphaFold Predicted Contacts for Alpha-Helical Transmembrane Proteins Using Structural Features.International journal of molecular sciences · 2024Article
- Oligomeric assembly of the C-terminal and transmembrane region of SARS-CoV-2 nsp3.Journal of virology · 2024Article
- Improving AlphaFold predicted contacts in alpha-helical transmembrane proteins structures using structural features.Research square · 2023Article
- Article
- Computational approaches for molecular characterization and structure-based functional elucidation of a hypothetical protein from Mycobacterium tuberculosis.Genomics & informatics · 2023Article
- A Structural Analysis of Proteinaceous Nanotube Cavities and Their Applications in Nanotechnology.Nanomaterials (Basel, Switzerland) · 2022Review
- Wenxiang 3.0: Evolutionary Visualization of α, π, and 3/10 Helices.Evolutionary bioinformatics online · 2022Review
- Rhodopsins: An Excitingly Versatile Protein Species for Research, Development and Creative Engineering.Frontiers in chemistry · 2022Review
- Mcl-1 and Bok transmembrane domains: Unexpected players in the modulation of apoptosis.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- A Conserved Proline Hinge Mediates Helix Dynamics and Activation of Rhodopsin.Structure (London, England : 1993) · 2020Article
- Linking Biochemical and Structural States of SERCA: Achievements, Challenges, and New Opportunities.International journal of molecular sciences · 2020Review
- Conformational changes in Apolipoprotein N-acyltransferase (Lnt).Scientific reports · 2020Article
- Structural basis of molecular logic OR in a dual-sensor histidine kinase.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- PiPred - a deep-learning method for prediction of π-helices in protein sequences.Scientific reports · 2019Article
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Authors and funding
4 authors.
Funding
Abstract
The seven-helical bundle of rhodopsin and other G-protein coupled receptors undergoes structural rearrangements as the transmembrane receptor protein is activated. These structural changes are known to involve tilting and bending of various transmembrane helices. However, the cause and effect relationship among structural events leading to a cytoplasmic crevasse for G-protein binding is less well defined. Here we present a mathematical model of the protein helix and a simple procedure to determine multiple parameters that offer precise depiction of a helical conformation. A comprehensive survey of bovine rhodopsin structures shows that the helical rearrangements during the activation of rhodopsin involve a variety of angular and linear motions such as torsion, unwinding, and sliding in addition to the previously reported tilting and bending. These hitherto undefined motion components unify the results obtained from different experimental approaches, and demonstrate conformational similarity between the active opsin structure and the photoactivated structures in crystallo near the retinal anchor despite their marked differences.
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Registered trials
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