ArticleHaematologica2017
Erythroferrone contributes to hepcidin repression in a mouse model of malarial anemia.
Article in Haematologica, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 40 citations in OpenAlex.
- Tissue-Resident Macrophages: Linking Physiology and Inflammation in Infection.Clinical reviews in allergy & immunology · 2026Review
- The Gut-Iron-Immune Axis in Severe Anaemia and Bacteraemia.Nutrients · 2026Review
- Host defense peptides in malaria infection: their contributions, significance and constraints.Malaria journal · 2025Review
- Expression of the FAM132B Gene in Iranian Patients with Beta-Thalassemia.International journal of hematology-oncology and stem cell research · 2025Article
- Pharmacologic Inhibition of Erythrocyte Ferroportin Expression ExacerbatesMicroorganisms · 2025Article
- Anemia of Inflammation.Advances in experimental medicine and biology · 2025Review
- Hormones in malaria infection: influence on disease severity, host physiology, and therapeutic opportunities.Bioscience reports · 2024Review
- Review
- Article
- Cutaneous leishmaniasis and iron metabolism: current insights and challenges.Frontiers in immunology · 2024Review
- Hepcidin regulation in Kenyan children with severe malaria and non-typhoidalHaematologica · 2022Article
- Characterization of Erythroferrone in a Teleost Fish (Frontiers in immunology · 2022Article
- Deferiprone-Resveratrol Hybrid, an Iron-Chelating Compound, Acts as an Antimalarial and Hepatoprotective Agent inBioinorganic chemistry and applications · 2022Article
- Physiology and Inflammation Driven Pathophysiology of Iron Homeostasis-Mechanistic Insights into Anemia of Inflammation and Its Treatment.Nutrients · 2021Review
- Using the Zebrafish as a Genetic Model to Study Erythropoiesis.International journal of molecular sciences · 2021Review
- C1q Complement/Tumor Necrosis Factor-Associated Proteins in Cardiovascular Disease and COVID-19.Proteomes · 2021Review
- How Severe Anaemia Might Influence the Risk of Invasive Bacterial Infections in African Children.International journal of molecular sciences · 2020Review
- Protein Modifications Critical for Myonectin/Erythroferrone Secretion and Oligomer Assembly.Biochemistry · 2020Article
- The diagnostic potential of the iron-regulatory hormone hepcidin.HemaSphere · 2019Article
- Anemia of inflammation.Blood · 2019Review
Corrections and comments
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Authors and funding
9 authors at 6 institutions in 3 countries.
Funding
Abstract
Malaria, a major global health challenge worldwide, is accompanied by a severe anemia secondary to hemolysis and increased erythrophagocytosis. Iron is an essential functional component of erythrocyte hemoglobin and its availability is controlled by the liver-derived hormone hepcidin. We examined the regulation of hepcidin during malarial infection in mice using the rodent parasite Plasmodium berghei K173. Mice infected with Plasmodium berghei K173 develop a severe anemia and die after 18 to 22 days without cerebral malaria. During the early phase of blood-stage infection (days 1 to 5), a strong inflammatory signature was associated with an increased production of hepcidin. Between days 7 and 18, while infection progressed, red blood cell count, hemoglobin and hematocrit dramatically decreased. In the late phase of malarial infection, hepcidin production was reduced concomitantly to an increase in the messenger RNA expression of the hepcidin suppressor erythroferrone in the bone marrow and the spleen. Compared with wild-type mice, Erfe
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.