ArticleEnvironmental science and pollution research international2016
Stereoselective toxicity of etoxazole to MCF-7 cells and its dissipation behavior in citrus and soil.
Article in Environmental science and pollution research international, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Screening for unconventional pesticides in tropical fruits and vegetables from Hainan, China.PloS one · 2026Article
- Article
- Alleviatory efficacy of achillea millefolium L. in etoxazole-mediated toxicity in allium cepa L.Scientific reports · 2024Article
- Risk assessment of oxidative stress and multiple toxicity induced by Etoxazole.Scientific reports · 2022Article
- Chiral Separation and Determination of Etoxazole Enantiomers in Vegetables by Normal-Phase and Reverse-Phase High Performance Liquid Chromatography.Molecules (Basel, Switzerland) · 2020Article
- Residue, dissipation, and safety evaluation of etoxazole and pyridaben in Goji berry under open-field conditions in the China's Qinghai-Tibet Plateau.Environmental monitoring and assessment · 2019Article
Corrections and comments
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Authors and funding
5 authors.
Funding
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Abstract
The stereoselective cytotoxicity of new chiral acaricide etoxazole and its dissipation in citrus and soil were investigated for the first time. Enantioselective toxicity and oxidative stress of etoxazole toward MCF-7 cells was conducted. The phenomenon of dose- and form-dependent cytotoxicity was demonstrated by MTT and LDH assays, ROS generation, and SOD and CAT activity alternation. Cytotoxicity ranks were found to be consistent with oxidative damage as (R)- > Rac- > (S)-etoxazole. Moreover, the results of enantioselective degradation showed that (S)-etoxazole degraded faster than its antipode (R)-etoxazole. The gradual raise of EF values indicated the achievement of enantioselective degradation in citrus and soil, leaving the enrichment of (R)-etoxazole isomer. Significant differences of environmental behavior and cytotoxicity of etoxazole enantiomers were found in this study which provided valuable insight into the mechanism of potential toxicity and warranted more careful assessment of this pesticide before its agricultural application.
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Registered trials
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