ArticlePloS one
Growth in Total Height and Its Components and Cardiometabolic Health in Childhood.
Article in PloS one. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 12 citations in OpenAlex.
- Upper Arm to Upper Leg Length Ratio and Dyslipidemia: A Novel Application of a Fixed Skeletal Proportion Metric in a Nationally Representative U.S. Sample.International journal of environmental research and public health · 2026Article
- Birth conditions nutritional status in childhood associated with cardiometabolic risk factors at 30 years of age: a cohort study.Cadernos de saude publica · 2023Article
- Exposure to obesogenic endocrine disrupting chemicals and obesity among youth of Latino or Hispanic origin in the United States and Latin America: A lifecourse perspective.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2021Review
- Longitudinal associations between body composition and regional fat distribution and later attained height at school entry among preschool children predisposed to overweight.European journal of clinical nutrition · 2020Article
- Leptin trajectories from birth to mid-childhood and cardio-metabolic health in early adolescence.Metabolism: clinical and experimental · 2019Observational
- Patterns of body mass index milestones in early life and cardiometabolic risk in early adolescence.International journal of epidemiology · 2019Article
- Association of Weight for Length vs Body Mass Index During the First 2 Years of Life With Cardiometabolic Risk in Early Adolescence.JAMA network open · 2018Article
- Growth across life course and cardiovascular risk markers in 18-year-old adolescents: the 1993 Pelotas birth cohort.BMJ open · 2018Article
- DNA methylation in blood as a mediator of the association of mid-childhood body mass index with cardio-metabolic risk score in early adolescence.Epigenetics · 2018Article
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Authors and funding
8 authors at 6 institutions in 2 countries.
Funding
Abstract
backgroundShort stature or short legs is associated with cardiometabolic disease. Few studies have addressed this issue in children, incorporated repeated measures, or studied modern cohorts.
methodsWe examined if change in total height, leg length and trunk length between two time points from early (median: 3.2 years) to mid-childhood (median: 7.7 years), with and without adjustment for concurrent change in adiposity (subscapular plus triceps skinfold thickness), was associated with mid-childhood cardiometabolic risk in 315 boys and 295 girls from Project Viva. The main outcome was a cardiometabolic risk score based on sex-specific internal z-scores for systolic blood pressure, waist circumference, homeostatic model assessment of insulin resistance, triglycerides and high-density lipoprotein-cholesterol.
resultsMean (SD) total height was 97.9 (4.5) cm in boys and 97.1 (4.7) cm in girls in early childhood and 129.1 (7.2) cm in boys and 128.3 (7.9) cm in girls in mid-childhood. Trunk length constituted about half of total height. In linear regression models adjusted for parental anthropometry and socio-demographics, faster growth in total height, leg length and particularly trunk length, were associated with higher cardiometabolic risk in mid-childhood. Per 1 cm annual increase in trunk length, the cardiometabolic risk score was 0.23 z-score (95% confidence interval [CI] 0.08, 0.39) higher among boys and 0.47 z-score (95% CI 0.33, 0.60) higher among girls. Estimates were attenuated after adjusting for adiposity (boys: 0.03 z-score, 95% CI -0.11, 0.18; girls: 0.32 z-score, 95% CI 0.19, 0.45).
conclusionRapid linear growth, particularly in trunk length, was associated with higher cardiometabolic risk in childhood, which was explained by relationships of linear growth with adiposity in boys, but only partly in girls.
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Registered trials
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