Evidence map›Paper›PMID 27658230›Full record

ArticleAging2016

Age-associated repression of type 1 inositol 1, 4, 5-triphosphate receptor impairs muscle regeneration.

Jeong Yi Choi, Chae Young Hwang, Bora Lee, Seung-Min Lee, Young Jae Bahn, Kwang-Pyo Lee, Moonkyung Kang, Yeon-Soo Kim, Sun-Hee Woo, Jae-Young Lim and 2 more

Open access · hybridAbstract read
In one paragraph

Article in Aging, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.

  1. Pooled it
  2. Science advances · 2025
    Article
  3. Article
  4. Article
  5. Effects of aging on calcium channels in skeletal muscle.Frontiers in molecular biosciences · 2025
    Review
  6. Article
  7. Age-dependent expression of ion channel genes in rat.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2023
    Article
  8. Polycystin-2 (PC2) is a key determinant of in vitro myogenesis.American journal of physiology. Cell physiology · 2022
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Jeong Yi ChoiAging Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon 34141, Republic of Korea.
Chae Young HwangAging Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon 34141, Republic of Korea.
Bora LeeAging Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon 34141, Republic of Korea.
Seung-Min LeeAging Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon 34141, Republic of Korea.
Young Jae BahnAging Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon 34141, Republic of Korea.
Kwang-Pyo LeeAging Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon 34141, Republic of Korea.
Moonkyung KangGraduate School of New Drug Discovery & Development, Chungnam National University, Daejeon 34143, Republic of Korea.
Yeon-Soo KimGraduate School of New Drug Discovery & Development, Chungnam National University, Daejeon 34143, Republic of Korea.
Sun-Hee WooCollege of Pharmacy, Chungnam National University, Daejeon 34143, Republic of Korea.
Jae-Young LimDepartment of Rehabilitation Medicine, Seoul National University Bundang Hospital, Gyeonggi-do 13620, Republic of Korea.
Eunhee KimCollege of Biological Science and Biotechnology, Chungnam National University, Daejeon 34134, Republic of Korea.
Ki-Sun KwonAging Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon 34141, Republic of Korea.
Korea Research Institute of Bioscience and Biotechnology · KRChungnam National University · KRSeoul National University Bundang Hospital · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Skeletal muscle mass and power decrease with age, leading to impairment of mobility and metabolism in the elderly. Ca

Indexed as

AdultAgedAge FactorsAgingAnimalsCalciumCalcium SignalingCells, CulturedHumansInositol 1,4,5-Trisphosphate ReceptorsMiceMiddle AgedMuscle DevelopmentMuscle, SkeletalMyoblastsPhenotypeCalciumInositol 1,4,5-Trisphosphate ReceptorsITPR1 protein, humanITPR1muscle agingmuscle regenerationsarcopeniaU0126

Identifiers

PMID27658230
PMCPMC5076452
OpenAlexW2413154103

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.