ArticlePLoS genetics2016
Sex-Specific Selection and Sex-Biased Gene Expression in Humans and Flies.
Article in PLoS genetics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
75 citing papers in PubMed, 146 citations in OpenAlex.
- Sexual selection purges mutation load, but not overall genetic diversity, decreasing vulnerability to extinction.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Analysis of the impact of gene evolution on reproductive effects reveals prevalent sexual and germline-soma conflicts.Nature ecology & evolution · 2026Article
- Conservation and divergence of sex-biased gene expression across 50 million years of Drosophila evolution.Molecular biology and evolution · 2026Article
- Drivers of systemic male-female allele frequency divergence in humans.bioRxiv : the preprint server for biology · 2026Article
- ZW and XY Sex Chromosomes Drive Rapid and Distinctive Evolution of Sex-Biased Gene Expression.Molecular ecology · 2025Article
- Pervasive sex-dependent effects in the genetic architecture of starvation resistance inScience advances · 2025Article
- Opinion: Why Sex-Based Genomic Differentiation Should Not Be Overlooked in Population Genetics.Molecular ecology · 2025Article
- Sex-Biased Gene Expression Under Sexually Antagonistic and Sex-Limited Selection.Molecular biology and evolution · 2025Article
- Testing for the Genomic Footprint of Conflict Between Life Stages in an Angiosperm and Moss Species.Genome biology and evolution · 2025Article
- Sexual Antagonism and Sex Determination in Three Syngnathid Species Alongside a Male Pregnancy Gradient.Genome biology and evolution · 2025Article
- Expression Divergence in Response to Sex-biased Selection.Molecular biology and evolution · 2025Article
- The potential of inversions to accumulate balanced sexual antagonism is supported by simulations andeLife · 2025Article
- The maintenance of genetic polymorphism underlying sexually antagonistic traits.Evolution letters · 2025Article
- No evidence for sex-differential transcriptomes driving genome-wide sex-differential natural selection.American journal of human genetics · 2025Article
- The release of sexual conflict after sex loss is associated with evolutionary changes in gene expression.Proceedings. Biological sciences · 2025Article
- Identification of Sex-Specific and Sex-Biased Transcripts for Genetic Sexing.Methods in molecular biology (Clifton, N.J.) · 2025Article
- Sex-biased gene content is associated with sex chromosome turnover in Danaini butterflies.Molecular ecology · 2024Article
- Cis-regulatory Variation in Relation to Sex and Sexual Dimorphism in Drosophila melanogaster.Genome biology and evolution · 2024Article
- The battle of the sexes in humans is highly polygenic.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Two novel genomes of fireflies with different degrees of sexual dimorphism reveal insights into sex-biased gene expression and dosage compensation.Communications biology · 2024Article
15 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Sexual dimorphism results from sex-biased gene expression, which evolves when selection acts differently on males and females. While there is an intimate connection between sex-biased gene expression and sex-specific selection, few empirical studies have studied this relationship directly. Here we compare the two on a genome-wide scale in humans and flies. We find a distinctive "Twin Peaks" pattern in humans that relates the strength of sex-specific selection, quantified by genetic divergence between male and female adults at autosomal loci, to the degree of sex-biased expression. Genes with intermediate degrees of sex-biased expression show evidence of ongoing sex-specific selection, while genes with either little or completely sex-biased expression do not. This pattern apparently results from differential viability selection in males and females acting in the current generation. The Twin Peaks pattern is also found in Drosophila using a different measure of sex-specific selection acting on fertility. We develop a simple model that successfully recapitulates the Twin Peaks. Our results suggest that many genes with intermediate sex-biased expression experience ongoing sex-specific selection in humans and flies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.