Evidence map›Paper›PMID 27657933›Full record

ArticlePloS one

Angiotensin-Converting Enzyme Insertion/Deletion Polymorphism and Susceptibility to Osteoarthritis of the Knee: A Case-Control Study and Meta-Analysis.

Chin Lin, Hsiang-Cheng Chen, Wen-Hui Fang, Chih-Chien Wang, Yi-Jen Peng, Herng-Sheng Lee, Hung Chang, Chi-Ming Chu, Guo-Shu Huang, Wei-Teing Chen and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 2 pooled it
0.6field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 2 syntheses or guidelines pooled it, 8 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Review
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 1 country.

Chin LinSchool of Public Health, National Defense Medical Center, Taipei, Taiwan, ROC.
Hsiang-Cheng ChenDivision of Rheumatology/Immunology/Allergy, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, ROC.
Wen-Hui FangDepartment of Family and Community Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, ROC.
Chih-Chien WangDepartment of Orthopedics, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, ROC.
Yi-Jen PengDepartment of Pathology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, ROC.
Herng-Sheng LeeDepartment of Pathology and Laboratory Medicine, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan, ROC.
Hung ChangDepartment of Physiology and Biophysics, National Defense Medical Center, Taipei, Taiwan‏, ROC.
Chi-Ming ChuSchool of Public Health, National Defense Medical Center, Taipei, Taiwan, ROC.
Guo-Shu HuangDepartment of Radiology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, ROC.
Wei-Teing ChenDepartment of Medicine, Cheng Hsin General Hospital, Taipei, Taiwan, ROC.
Yu-Jui TsaiSchool of Public Health, National Defense Medical Center, Taipei, Taiwan, ROC.
Hong-Ling LinSchool of Public Health, National Defense Medical Center, Taipei, Taiwan, ROC.
Fu-Huang LinSchool of Public Health, National Defense Medical Center, Taipei, Taiwan, ROC.
Sui-Lung SuSchool of Public Health, National Defense Medical Center, Taipei, Taiwan, ROC.
National Defense Medical Center · TWTri-Service General Hospital · TWKaohsiung Veterans General Hospital · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundStudies of angiotensin-converting enzyme insertion/deletion (ACE I/D) polymorphisms and the risks of knee osteoarthritis (OA) have yielded conflicting results.

objectiveTo determine the association between ACE I/D and knee OA, we conducted a combined case-control study and meta-analysis.

methodsFor the case-control study, 447 knee OA cases and 423 healthy controls were recruited between March 2010 and July 2011. Knee OA cases were defined using the Kellgren-Lawrence grading system, and the ACE I/D genotype was determined using a standard polymerase chain reaction. The association between ACE I/D and knee OA was detected using allele, genotype, dominant, and recessive models. For the meta-analysis, PubMed and Embase databases were systematically searched for prospective observational studies published up until August 2015. Studies of ACE I/D and knee OA with sufficient data were selected. Pooled results were expressed as odds ratios (ORs) with corresponding 95% confidence intervals (CI) for the D versus I allele with regard to knee OA risk.

resultsWe found no significant association between the D allele and knee OA [OR: 1.09 (95% CI: 0.76-1.89)] in the present case-control study, and the results of other genetic models were also nonsignificant. Five current studies were included, and there were a total of six study populations after including our case-control study (1165 cases and 1029 controls). In the meta-analysis, the allele model also yielded nonsignificant results [OR: 1.37 (95% CI: 0.95-1.99)] and a high heterogeneity (I2: 87.2%).

conclusionsThe association between ACE I/D and knee OA tended to yield negative results. High heterogeneity suggests a complex, multifactorial mechanism, and an epistasis analysis of ACE I/D and knee OA should therefore be conducted.

Identifiers

PMID27657933
PMCPMC5033346
OpenAlexW2523327874

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.