ArticlePLoS neglected tropical diseases2016
Molecular Surveillance Identifies Multiple Transmissions of Typhoid in West Africa.
Article in PLoS neglected tropical diseases, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 4 of them syntheses that pooled it.
What it found
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The trial behind it
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Who cites it
33 citing papers in PubMed, 4 syntheses or guidelines pooled it, 111 citations in OpenAlex.
- Pooled it
- A systematic review of antimicrobial resistance of typhoidalThe Indian journal of medical research · 2019Pooled it
- A systematic review of antimicrobial resistance in Salmonella enterica serovar Typhi, the etiological agent of typhoid.PLoS neglected tropical diseases · 2018Pooled it
- Molecular epidemiology of fluoroquinolone resistant Salmonella in Africa: A systematic review and meta-analysis.PloS one · 2018Pooled it
- Safety and Efficacy of a Typhoid Conjugate Vaccine in Malawian Children.The New England journal of medicine · 2021Trial
- Typhoid Vaccine Acceleration Consortium Malawi: A Phase III, Randomized, Double-blind, Controlled Trial of the Clinical Efficacy of Typhoid Conjugate Vaccine Among Children in Blantyre, Malawi.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2019Trial
- Emergence of Genotype 2.3.1 Multidrug-Resistant Salmonella enterica Serovar Typhi Strain, West Africa, 2021-2025.Emerging infectious diseases · 2026Article
- Article
- Estimating the subnational prevalence of antimicrobial resistant Salmonella enterica serovars Typhi and Paratyphi A infections in 75 endemic countries, 1990-2019: a modelling study.The Lancet. Global health · 2024Article
- Antimicrobial resistance and virulence genes of invasiveSAGE open medicine · 2023Article
- Genomic characterization of invasive typhoidal and non-typhoidal Salmonella in southwestern Nigeria.PLoS neglected tropical diseases · 2022Article
- The international and intercontinental spread and expansion of antimicrobial-resistant Salmonella Typhi: a genomic epidemiology study.The Lancet. Microbe · 2022Article
- Molecular characterization of circulating Salmonella Typhi strains in an urban informal settlement in Kenya.PLoS neglected tropical diseases · 2022Article
- Genomic epidemiology ofThe Lancet regional health. Western Pacific · 2022Article
- Whole genome sequence analysis of Salmonella Typhi provides evidence of phylogenetic linkage between cases of typhoid fever in Santiago, Chile in the 1980s and 2010-2016.PLoS neglected tropical diseases · 2022Article
- Whole genome sequence analysis of Salmonella Typhi in Papua New Guinea reveals an established population of genotype 2.1.7 sensitive to antimicrobials.PLoS neglected tropical diseases · 2022Review
- Emerging Trends of Multidrug-Resistant (MDR) and Extensively Drug-Resistant (XDR)Microorganisms · 2021Article
- Increasingly limited options for the treatment of enteric fever in travellers returning to England, 2014-2019: a cross-sectional analytical study.Journal of medical microbiology · 2021Article
- Population structure and antimicrobial resistance patterns of Salmonella Typhi isolates in urban Dhaka, Bangladesh from 2004 to 2016.PLoS neglected tropical diseases · 2020Article
- Chromosomal and plasmid-mediated fluoroquinolone resistance in human Salmonella enterica infection in Ghana.BMC infectious diseases · 2019Article
Corrections and comments
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Authors and funding
32 authors at 20 institutions in 13 countries.
Funding
Abstract
backgroundThe burden of typhoid in sub-Saharan African (SSA) countries has been difficult to estimate, in part, due to suboptimal laboratory diagnostics. However, surveillance blood cultures at two sites in Nigeria have identified typhoid associated with Salmonella enterica serovar Typhi (S. Typhi) as an important cause of bacteremia in children.
methodsA total of 128 S. Typhi isolates from these studies in Nigeria were whole-genome sequenced, and the resulting data was used to place these Nigerian isolates into a worldwide context based on their phylogeny and carriage of molecular determinants of antibiotic resistance.
resultsSeveral distinct S. Typhi genotypes were identified in Nigeria that were related to other clusters of S. Typhi isolates from north, west and central regions of Africa. The rapidly expanding S. Typhi clade 4.3.1 (H58) previously associated with multiple antimicrobial resistances in Asia and in east, central and southern Africa, was not detected in this study. However, antimicrobial resistance was common amongst the Nigerian isolates and was associated with several plasmids, including the IncHI1 plasmid commonly associated with S. Typhi.
conclusionsThese data indicate that typhoid in Nigeria was established through multiple independent introductions into the country, with evidence of regional spread. MDR typhoid appears to be evolving independently of the haplotype H58 found in other typhoid endemic countries. This study highlights an urgent need for routine surveillance to monitor the epidemiology of typhoid and evolution of antimicrobial resistance within the bacterial population as a means to facilitate public health interventions to reduce the substantial morbidity and mortality of typhoid.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.