ArticleNature chemistry2016
Oligoarginine peptides slow strand annealing and assist non-enzymatic RNA replication.
Article in Nature chemistry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed.
- Stabilization of Polymer-Polyoxometalate Coacervate Droplets by Divalent Cations.ACS macro letters · 2026Article
- Coacervate-Based Delivery Systems: Bridging Fundamentals and Applications.ACS applied materials & interfaces · 2025Review
- Peptide-based coacervates in therapeutic applications.Frontiers in bioengineering and biotechnology · 2022Review
- In Situ Monitoring of MicroRNA Replacement Efficacy and Accurate Imaging-Guided Cancer Therapy through Light-Up Inter-Polyelectrolyte Nanocomplexes.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2018Article
- What Does "the RNA World" Mean to "the Origin of Life"?Life (Basel, Switzerland) · 2017Article
- Emergence of a New Self-Replicator from a Dynamic Combinatorial Library Requires a Specific Pre-Existing Replicator.Journal of the American Chemical Society · 2017Article
- Simple peptides derived from the ribosomal core potentiate RNA polymerase ribozyme function.Nature chemistry · 2017Article
- From chemical metabolism to life: the origin of the genetic coding process.Beilstein journal of organic chemistry · 2017Review
- N-Carboxyanhydride-Mediated Fatty Acylation of Amino Acids and Peptides for Functionalization of Protocell Membranes.Journal of the American Chemical Society · 2016Article
Corrections and comments
- Retraction · 2017-11-23Error in Analyses · Results Not Reproducible ·
- Retracted
Authors and funding
5 authors.
Funding
Abstract
The non-enzymatic replication of RNA is thought to have been a critical process required for the origin of life. One unsolved difficulty with non-enzymatic RNA replication is that template-directed copying of RNA results in a double-stranded product. After strand separation, rapid strand reannealing outcompetes slow non-enzymatic template copying, which renders multiple rounds of RNA replication impossible. Here we show that oligoarginine peptides slow the annealing of complementary oligoribonucleotides by up to several thousand-fold; however, short primers and activated monomers can still bind to template strands, and template-directed primer extension can still occur, all within a phase-separated condensed state, or coacervate. Furthermore, we show that within this phase, partial template copying occurs even in the presence of full-length complementary strands. This method to enable further rounds of replication suggests one mechanism by which short non-coded peptides could have enhanced early cellular fitness, and potentially explains how longer coded peptides, that is, proteins, came to prominence in modern biology.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.