ArticlePloS one
Differences in Cytokine Expression and STAT3 Activation between Healthy Controls and Patients of Unexplained Recurrent Spontaneous Abortion (URSA) during Early Pregnancy.
Article in PloS one. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.
- Efficacy and safety of Gushen Antai Pills combined with dydrogesterone in the treatment of threatened miscarriage: a systematic review and meta-analysis.Frontiers in pharmacology · 2023Pooled it
- The Role of Interleukin-17, Interleukin-23, and Transforming Growth Factor-BioMed research international · 2017Trial
- The use of autologous platelet-rich plasma in embryo culture to obtain high-quality embryos.Scientific reports · 2025Article
- Understanding the role of immune-mediated inflammatory disease related cytokines interleukin 17 and 23 in pregnancy: A systematic review.Journal of translational autoimmunity · 2025Review
- The role of miRNA molecules in the miscarriage process.Biology of reproduction · 2023Article
- Possible Role ofInternational journal of fertility & sterility · 2023Article
- Research progress on the STAT signaling pathway in pregnancy and pregnancy-associated disorders.Frontiers in immunology · 2023Review
- The Update Immune-Regulatory Role of Pro- and Anti-Inflammatory Cytokines in Recurrent Pregnancy Losses.International journal of molecular sciences · 2022Review
- Immunogenetic Role of IL17A Polymorphism in the Pathogenesis of Recurrent Miscarriage.Journal of clinical medicine · 2022Article
- Article
- RNA Sequencing of Decidua Reveals Differentially Expressed Genes in Recurrent Pregnancy Loss.Reproductive sciences (Thousand Oaks, Calif.) · 2021Article
- Considerations on inhibition of IL-23 in psoriatic women of childbearing potential.Dermatologic therapy · 2021Article
- Review
- The exploration of Hashimoto's Thyroiditis related miscarriage for better treatment modalities.International journal of medical sciences · 2020Review
- Prednisone may rebuild the immunologic homeostasis: Alteration of Th17 and Treg cells in the lymphocytes from rats' spleens after treated with prednisone-containing serum.Molecular genetics & genomic medicine · 2019Article
- IL-17 blood levels increase in healthy pregnancy but not in spontaneous abortion.Molecular biology reports · 2018Article
- Women with recurrent spontaneous abortion have decreased 25(OH) vitamin D and VDR at the fetal-maternal interface.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2017Article
- Tumor Necrosis Factor-Alpha and Pregnancy: Focus on Biologics. An Updated and Comprehensive Review.Clinical reviews in allergy & immunology · 2017Review
- BRD4 Inhibitor Alleviates Recurrent Spontaneous Abortion via Regulating BRD4/STAT3/IL-17A Axis to Decrease the Th17 Cell Differentiation.Reproductive medicine and biologyArticle
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Unexplained recurrent spontaneous abortion (URSA) is a common complication of pregnancy. Although tolerance of the maternal immune system is considered to be essential for a normal pregnancy, the precise mechanism underlying the pathogenesis of URSA remains to be fully elucidated, albeit it is known to involve inflammation. Here, we examine the relationship between the expression of inflammatory cytokines and the activation of downstream signaling pathways in URSA patients. Decidual and peripheral blood samples were collected from 30 URSA patients and from 30 women with normal early pregnancies. Western blot analysis was used to measure the expression levels of signal transducers and activators of transcription 3(STAT3), phosphorylated STAT3(p-STAT3), and interleukin-17 receptor(IL-17R) in the decidual samples. Enzyme-linked immunosorbent assay was used to assess the levels of IL-17, IL-10, IL-6, and IL-23 in the peripheral blood and decidual samples. In the URSA patients, the IL-10 expression levels were lower than those in the control subjects (P<0.05), whereas IL-6, IL-17, and IL-23 were all expressed at higher levels(P<0.05). Furthermore, the expression levels of IL-17R and p-STAT3 were higher in the URSA patients, exhibiting a trend similar to that of IL-23. Our finding of increased IL-23 expression in the deciduae and peripheral blood of patients with URSA suggest that this maybe a contributing factor to the pathogenesis of this disease. Likewise, STAT3 activation through its phosphorylation, which was associated with the IL-23 increase, may also be involved in URSA pathogenesis. However, the precise pathogenic mechanism requires further study.
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Registered trials
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