Biomimetic Precapillary Flow Patterns for Enhancing Blood Plasma Separation: A Preliminary Study.

Bumseok Namgung, Justin Kok Soon Tan, Peter Agustinus Wong, Sung-Yong Park, Hwa Liang Leo, Sangho Kim

Abstract read

In one paragraph

Article in Sensors (Basel, Switzerland), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Bumseok NamgungDepartment of Biomedical Engineering, National University of Singapore, Singapore 117583, Singapore. cienab@nus.edu.sg.

Justin Kok Soon TanDepartment of Biomedical Engineering, National University of Singapore, Singapore 117583, Singapore. bietksj@nus.edu.sg.

Peter Agustinus WongDepartment of Biomedical Engineering, National University of Singapore, Singapore 117583, Singapore. peter.wong@u.nus.edu.

Sung-Yong ParkDepartment of Mechanical Engineering, National University of Singapore, Singapore 117575, Singapore. mpeps@nus.edu.sg.

Hwa Liang LeoDepartment of Biomedical Engineering, National University of Singapore, Singapore 117583, Singapore. bielhl@nus.edu.sg.

Sangho KimDepartment of Biomedical Engineering, National University of Singapore, Singapore 117583, Singapore. bieks@nus.edu.sg.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In this study, a biomimetic microfluidic plasma separation device is discussed. The design of the device drew inspiration from in vivo observations of enhanced cell-free layer (CFL) formation downstream of vascular bifurcations. The working principle for the plasma separation was based on the plasma skimming effect in an arteriolar bifurcation, which is modulated by CFL formation. The enhancement of the CFL width was achieved by a local hematocrit reduction near the collection channel by creating an uneven hematocrit distribution at the bifurcation of the channel. The device demonstrated a high purity of separation (~99.9%) at physiological levels of hematocrit (~40%).

Indexed as

cell-free layerhemodynamicshydrodynamic separationmicrofluidics

Identifiers

PMID27657090

DOI10.3390/s16091543

PMCPMC5038815

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.