ArticleInternational journal of molecular sciences2016
McDonald Criteria 2010 and 2005 Compared: Persistence of High Oligoclonal Band Prevalence Despite Almost Doubled Diagnostic Sensitivity.
Article in International journal of molecular sciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 37 citations in OpenAlex.
- Prevalence of comorbid autoimmune diseases and antibodies in newly diagnosed multiple sclerosis patients.Neurological research and practice · 2024Article
- Clinical and paraclinical characteristics of optic neuritis in the context of the McDonald criteria 2017.Scientific reports · 2024Article
- Multiple sclerosis in a patient with Takayasu's Arteritis: A case report.Caspian journal of internal medicine · 2024Article
- Neurological management and work-up of neurotoxicity associated with CAR T cell therapy.Neurological research and practice · 2022Article
- The Aryl Hydrocarbon Receptor-Dependent TGF-α/VEGF-B Ratio Correlates With Disease Subtype and Prognosis in Multiple Sclerosis.Neurology(R) neuroimmunology & neuroinflammation · 2021Article
- Determination of CSF GFAP, CCN5, and vWF Levels Enhances the Diagnostic Accuracy of Clinically Defined MS From Non-MS Patients With CSF Oligoclonal Bands.Frontiers in immunology · 2021Article
- Evidence of Oligoclonal Bands Does Not Exclude Non-Inflammatory Neurological Diseases.Diagnostics (Basel, Switzerland) · 2020Article
- Cerebrospinal fluid findings in patients with myelin oligodendrocyte glycoprotein (MOG) antibodies. Part 1: Results from 163 lumbar punctures in 100 adult patients.Journal of neuroinflammation · 2020Article
- The Impact of Immunomodulatory Treatment on Kappa Free Light Chains as Biomarker in Neuroinflammation.Cells · 2020Article
- Healthcare, Sickness Absence, and Disability Pension Cost Trajectories in the First 5 Years After Diagnosis with Multiple Sclerosis: A Prospective Register-Based Cohort Study in Sweden.PharmacoEconomics - open · 2020Article
- Diagnosis and Differential Diagnosis of Neurological Adverse Events during Immune Checkpoint Inhibitor Therapy.Journal of oncology · 2020Article
- Reiber's Diagram for Kappa Free Light Chains: The New Standard for Assessing Intrathecal Synthesis?Diagnostics (Basel, Switzerland) · 2019Article
- Neuro-Sjögren: Peripheral Neuropathy With Limb Weakness in Sjögren's Syndrome.Frontiers in immunology · 2019Article
- Immunity in Gilles de la Tourette-Syndrome: Results From a Cerebrospinal Fluid Study.Frontiers in neurology · 2019Article
- Investigation of Oligoclonal IgG Bands in Tear Fluid of Multiple Sclerosis Patients.Frontiers in immunology · 2019Article
- Impact of the McDonald Criteria 2017 on Early Diagnosis of Relapsing-Remitting Multiple Sclerosis.Frontiers in neurology · 2019Review
- The Persisting Significance of Oligoclonal Bands in the Dawning Era of Kappa Free Light Chains for the Diagnosis of Multiple Sclerosis.International journal of molecular sciences · 2018Article
- Overinterpretation and Overtreatment of Low-Titer Antibodies Against Contactin-Associated Protein-2.Frontiers in immunology · 2018Article
- Clinically Isolated Syndrome According to McDonald 2010: Intrathecal IgG Synthesis Still Predictive for Conversion to Multiple Sclerosis.International journal of molecular sciences · 2017Article
- Common and uncommon neurological manifestations of neuroborreliosis leading to hospitalization.BMC infectious diseases · 2017Article
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Authors and funding
9 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
The 2010 McDonald criteria were developed to allow a more rapid diagnosis of relapsing-remitting multiple sclerosis (MS) by only one MRI of the brain. Although cerebrospinal fluid (CSF) is not a mandatory part of the latest criteria, the evidence of an intrathecal humoral immunoreaction in the form of oligoclonal bands (OCB) is crucial in the diagnostic workup. To date, the impact of the 2010 McDonald criteria on the prevalence of OCB has not been investigated. We retrospectively evaluated data of 325 patients with a clinical relapse suggestive of demyelination that were treated in a German university hospital between 2010 and 2015. One hundred thirty-six patients (42%) were diagnosed with MS and 189 patients with CIS when the criteria of 2010 were applied. The criteria of 2005 allowed only 70 patients (22%) to be designated as MS. In contrast, the prevalence of OCB was marginal affected in MS patients with 96% for the criteria of 2010 and 98.5% for the criteria of 2005. In conclusion, OCB are prevalent in most MS patients and reflect the chronic inflammatory nature of the disease. We recommend CSF examination to exclude alternative diagnoses and reevaluation of the diagnosis MS in patients with negative OCB.
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