ArticleJournal of exercise rehabilitation2016
Treadmill exercise ameliorates intracerebral hemorrhage-induced depression in rats.
Article in Journal of exercise rehabilitation, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 18 citations in OpenAlex.
- Review
- Neuroprotective efficacy of 4-Hydroxyisoleucine in experimentally induced intracerebral hemorrhage.Saudi journal of biological sciences · 2021Article
- Neuroprotective potential of solanesol in a combined model of intracerebral and intraventricular hemorrhage in rats.IBRO reports · 2020Article
- Running exercise protects oligodendrocytes in the medial prefrontal cortex in chronic unpredictable stress rat model.Translational psychiatry · 2019Article
- Effects of treadmill exercise on the anxiety-like behavior through modulation of GSK3β/β-catenin signaling in the maternal separation rat pup.Journal of exercise rehabilitation · 2019Article
- Treadmill Exercise Improves Motor Function by Suppressing Purkinje Cell Loss in Parkinson Disease Rats.International neurourology journal · 2018Article
- Dexmedetomidine Ameliorates Sleep Deprivation-Induced Depressive Behaviors in Mice.International neurourology journal · 2018Article
- Changes in motor function, cognition, and emotion-related behavior after right hemispheric intracerebral hemorrhage in various brain regions of mouse.Brain, behavior, and immunity · 2018Article
- Treadmill exercise ameliorates depressive symptoms through increasing serotonin expression in postpartum depression rats.Journal of exercise rehabilitation · 2017Article
- Dexmedetomidine Oral Mucosa Patch for Sedation Suppresses Apoptosis in Hippocampus of Normal Rats.International neurourology journal · 2017Article
- Treadmill exercise improves depression-like symptoms by enhancing serotonergic function through upregulation of 5-HTJournal of exercise rehabilitation · 2017Article
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Intracerebral hemorrhage (ICH) is a severe type of stroke causing neurological dysfunction with high mortality rate. Depression is one of the most common complications of ICH. In the present study, the effects of treadmill exercise on ICH-induced depressive symptoms in relation with apoptosis were investigated using rats. ICH rat model was induced by injection of collagenase into the hippocampus using stereotaxic instrument. Open field test for activity and forced swimming test for depressive symptoms were conducted. Apoptosis in the hippocampus was detected using terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling assay, immunohistochemistry for caspase-3, and western blot for Bcl-2 and Bax. Western blot analysis for 5-hydroxy-tryptamine (5-HT, serotonin) and tryptophan hydroxylase (TPH) in the dorsal raphe was also conducted for biomarkers of depression. In the present results, immobility time was increased and climbing time was decreased by induction of ICH and treadmill exercise inhibited immobility time and increased climbing time in ICH rats. DNA fragmentation and caspase-3 expression in the hippocampal dentate gyrus were enhanced by induction of ICH and treadmill exercise suppressed ICH-induced DNA fragmentation and caspase-3 expression. Bax expression in the hippocampus was increased by induction of ICH and treadmill exercise inhibited Bax expression in the ICH rats. Expressions of 5-HT and TPH in the dorsal raphe were decreased by induction of ICH and treadmill exercise increased expressions of 5-HT and TPH in the ICH rats. In the present study, treadmill exercise ameliorated depressive symptoms through inhibiting apoptosis.
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