ArticleMolecular metabolism2016
Optogenetic activation of leptin- and glucose-regulated GABAergic neurons in dorsomedial hypothalamus promotes food intake via inhibitory synaptic transmission to paraventricular nucleus of hypothalamus.
Article in Molecular metabolism, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 39 citations in OpenAlex.
- Paraventricular hypothalamic RUVBL2 neurons suppress appetite by enhancing excitatory synaptic transmission in distinct neurocircuits.Nature communications · 2024Article
- Optimized ultrasound neuromodulation for non-invasive control of behavior and physiology.Neuron · 2024Article
- The Diverse Network of Brain Histamine in Feeding: Dissect its Functions in a Circuit-Specific Way.Current neuropharmacology · 2024Review
- Review
- GABAergic leptin receptor-expressing neurons in the dorsomedial hypothalamus project to brown adipose tissue-related neurons in the paraventricular nucleus of mice.Autonomic neuroscience : basic & clinical · 2023Article
- Recent advances in understanding hypothalamic control of defensive responses to hypoglycaemia.Current opinion in endocrine and metabolic research · 2022Review
- Estrogenic regulation of reproduction and energy homeostasis by a triumvirate of hypothalamic arcuate neurons.Journal of neuroendocrinology · 2022Review
- The physiological control of eating: signals, neurons, and networks.Physiological reviews · 2022 · on this mapArticle
- Immunohistochemical Analysis of Neurotransmitters in Neurosecretory Protein GL-Producing Neurons of the Mouse Hypothalamus.Biomedicines · 2022Article
- Circadian Rhythms of the Hypothalamus: From Function to Physiology.Clocks & sleep · 2021Review
- Discrete TrkB-expressing neurons of the dorsomedial hypothalamus regulate feeding and thermogenesis.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Neural connectivity between the hypothalamic supramammillary nucleus and appetite- and motivation-related regions of the rat brain.Journal of neuroendocrinology · 2020Article
- GABAergic Inputs to POMC Neurons Originating from the Dorsomedial Hypothalamus Are Regulated by Energy State.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Central Mechanisms of Glucose Sensing and Counterregulation in Defense of Hypoglycemia.Endocrine reviews · 2019Review
- Systemic Glucose Administration Alters Water Diffusion and Microvascular Blood Flow in Mouse Hypothalamic Nuclei - An fMRI Study.Frontiers in neuroscience · 2019Article
- New insight into GABAergic neurons in the hypothalamic feeding regulation.The journal of physiological sciences : JPS · 2018Review
- Cholecystokinin Switches the Plasticity of GABA Synapses in the Dorsomedial Hypothalamus via Astrocytic ATP Release.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Investigating metabolic regulation using targeted neuromodulation.Annals of the New York Academy of Sciences · 2018Review
- Article
- Cholinergic neurons in the dorsomedial hypothalamus regulate food intake.Molecular metabolism · 2017Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe dorsomedial hypothalamus (DMH) has been considered an orexigenic nucleus, since the DMH lesion reduced food intake and body weight and induced resistance to diet-induced obesity. The DMH expresses feeding regulatory neuropeptides and receptors including neuropeptide Y (NPY), cocaine- and amphetamine-regulated transcript (CART), cholecystokinin (CCK), leptin receptor, and melanocortin 3/4 receptors. However, the principal neurons generating the orexigenic function in the DMH remain to be defined. This study aimed to clarify the role of the DMH GABAergic neurons in feeding regulation by using optogenetics and electrophysiological techniques.
methodsWe generated the mice expressing ChRFR-C167A, a bistable chimeric channelrhodopsin, selectively in GABAergic neurons of DMH via locally injected adeno-associated virus 2. Food intake after optogenetic activation of DMH GABAergic neurons was measured. Electrophysiological properties of DMH GABAergic neurons were measured using slice patch clamp.
resultsOptogenetic activation of DMH GABAergic neurons promoted food intake. Leptin hyperpolarized and lowering glucose depolarized half of DMH GABAergic neurons, suggesting their orexigenic property. Optical activation of axonal terminals of DMH GABAergic neurons at the paraventricular nucleus of hypothalamus (PVN), where anorexigenic neurons are localized, increased inhibitory postsynaptic currents on PVN neurons and promoted food intake.
conclusionDMH GABAergic neurons are regulated by metabolic signals leptin and glucose and, once activated, promote food intake via inhibitory synaptic transmission to PVN.
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