Evidence map›Paper›PMID 27656339›Full record

ArticleEuropean physical journal plus2015

Niche construction game cancer cells play.

Aviv Bergman, Bojana Gligorijevic

Abstract read
In one paragraph

Article in European physical journal plus, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Tumor Microenvironment - Selective Pressures Boosting Cancer Progression.Advances in experimental medicine and biology · 2020
    Review
  3. Article
  4. A systematic approach to cancer: evolution beyond selection.Clinical and translational medicine · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Aviv BergmanSystems and Computational Biology Department, Albert Einstein College of Medicine, 1301 Morris Park Ave, 10461, Bronx, NY, USA.
Bojana GligorijevicBioengineering Department, Temple University, 1947 N 12th st., 19122 Philadelphia, PA, USA; Cancer Biology Program, Fox Chase Cancer Center, Cottman Ave 333, 19111 Philadelphia, PA, USA.

Funding

In Vivo Multiphoton Based Imaging of Complex Cancer Cell BehaviorR01CA164468 · NCI · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI VERKHUSHA, VLADISLAV · 2011 to 2015
$3.8M
Systems biology analysis of in vivo impact of substance abuse on HIV infectionR01DA033788 · NIDA · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI GOLDSTEIN, HARRIS · 2012 to 2016
$3.0M
Systems Microscopy Analysis of Tumor Cell Motility in Microenvironment ContextR00CA172360 · NCI · TEMPLE UNIV OF THE COMMONWEALTH · PI GLIGORIJEVIC, BOJANA · 2015 to 2017
$747k
Systems microscopy analysis of tumor cell motility in microenvironment contextK99CA172360 · NCI · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI GLIGORIJEVIC, BOJANA · 2013 to 2014
$279k
NCI NIH HHS K99 CA172360NCI NIH HHS R00 CA172360NCI NIH HHS R01 CA164468NIDA NIH HHS R01 DA033788
6 · The paper itself

Abstract

Niche construction concept was originally defined in evolutionary biology as the continuous interplay between natural selection via environmental conditions and the modification of these conditions by the organism itself. Processes unraveling during cancer metastasis include construction of niches, which cancer cells use towards more efficient survival, transport into new environments and preparation of the remote sites for their arrival. Many elegant experiments were done lately illustrating, for example, the premetastatic niche construction, but there is practically no mathematical modeling done which would apply the

Identifiers

PMID27656339
PMCPMC5027994

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.