ArticleFrontiers in pharmacology2016
Hypoglycemic Activity and the Potential Mechanism of the Flavonoid Rich Extract from Sophora tonkinensis Gagnep. in KK-Ay Mice.
Article in Frontiers in pharmacology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 42 citations in OpenAlex.
- Curcumin extract improves beta cell functions in obese patients with type 2 diabetes: a randomized controlled trial.Nutrition journal · 2024Trial
- Biological Activities and Secondary Metabolites fromMolecules (Basel, Switzerland) · 2022Review
- Davidones F and G, Two Novel Flavonoids fromMolecules (Basel, Switzerland) · 2021Article
- The hypoglycemic effect of freeze-dried fermented mulberry mixed with soybean on type 2 diabetes mellitus.Food science & nutrition · 2021Article
- A biflavonoid-rich extract from Selaginella moellendorffii Hieron. induces apoptosis via STAT3 and Akt/NF-κB signalling pathways in laryngeal carcinoma.Journal of cellular and molecular medicine · 2020Article
- Antidiabetic effects of a lipophilic extract obtained from flowers ofFood & nutrition research · 2020Article
- Antidiarrheal activity of methanol extract ofPharmaceutical biology · 2019Article
- Preparative Purification of Total Flavonoids fromMolecules (Basel, Switzerland) · 2019Article
- Anti-inflammatory effects of naturally occurring retinoid X receptor agonists isolated from Sophora tonkinensis Gagnep. via retinoid X receptor/liver X receptor heterodimers.Journal of natural medicines · 2019Article
- Neferine Promotes GLUT4 Expression and Fusion With the Plasma Membrane to Induce Glucose Uptake in L6 Cells.Frontiers in pharmacology · 2019Article
- Ethanolic Extract of Folium Sennae Mediates the Glucose Uptake of L6 Cells by GLUT4 and CaMolecules (Basel, Switzerland) · 2018Article
- Insulin Mimetic Properties of Extracts Prepared fromMolecules (Basel, Switzerland) · 2018Article
- Antidiabetic Activity of a Flavonoid-Rich Extract FromFrontiers in pharmacology · 2018Article
- Quantitative Analysis, Extraction Optimization, and Biological Evaluation of Cudrania tricuspidata Leaf and Fruit Extracts.Molecules (Basel, Switzerland) · 2017Article
- Anti-diabetic activity of stigmasterol from soybean oil by targeting the GLUT4 glucose transporter.Food & nutrition research · 2017Article
- Hypoglycemic Potential of Aqueous Extract ofFrontiers in pharmacology · 2017Article
- Network Pharmacology Studies on the Bioactive Compounds and Action Mechanisms of Natural Products for the Treatment of Diabetes Mellitus: A Review.Frontiers in pharmacology · 2017Review
- Cassia Abbreviata Enhances Glucose Uptake and Glucose Transporter 4 Translocation in C2C12 Mouse Skeletal Muscle Cells.Journal of evidence-based integrative medicineArticle
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study investigated the active principles, hypoglycemic activity and potential mechanisms of the flavonoid rich extract from Sophora tonkinensis Gagnep. (ST-EtOAc) in KK-Ay diabetic mice. An off-line semipreparative liquid chromatography-nuclear magnetic resonance (LC-NMR) and liquid chromatography-ultraviolet-electrospray ionization mass spectrometry (LC-UV-ESIMS) protocol was performed to determine 13 flavonoids from ST-EtOAc. ST-EtOAc administrated orally to the KK-Ay mice significantly increased their sensibility to insulin, reduced fasting blood-glucose levels and blood lipid indexes such as triglyceride and cholesterol. Moreover, ST-EtOAc exhibited a strong effect of stimulation on glucose transporter 4 (GLUT4) translocation by 2.7-fold in L6 cells. However, the selective AMP-activated protein kinase (AMPK) inhibitor compound C can completely inhibit the activation of the AMPK pathway and prevent the GLUT4 translocation caused by ST-EtOAc. In vivo, phosphorylation of the AMPK expression in the liver and skeletal muscle was measured. The results showed phosphorylation of the AMPK had been improved and GLUT4 expression had been also enhanced. In this paper, we conclude that, ST-EtOAc seems to have potential beneficial effects on the treatment of type 2 diabetes mellitus with the probable mechanism of stimulating GLUT4 translocation modulated by the AMPK pathway.
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