ArticleFrontiers in behavioral neuroscience2016
Concurrence of High Fat Diet and APOE Gene Induces Allele Specific Metabolic and Mental Stress Changes in a Mouse Model of Alzheimer's Disease.
Article in Frontiers in behavioral neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 18 citations in OpenAlex.
- Article
- 2bRAD-M Reveals the Characteristics of Urinary Microbiota in Overweight Patients with Urinary Tract Stones.Biomedicines · 2025Article
- Predictive link between systemic metabolism and cytokine signatures in the brain of apolipoprotein E ε4 mice.Neurobiology of aging · 2023Article
- Diet and Anxiety: A Scoping Review.Nutrients · 2021Article
- Sex and Exposure to Postnatal Chlorpyrifos Influence the Epigenetics of Feeding-Related Genes in a TransgenicInternational journal of environmental research and public health · 2020Article
- Measuring mRNA translation in neuronal processes and somata by tRNA-FRET.Nucleic acids research · 2020Article
- Central and Peripheral Mechanisms in ApoE4-Driven Diabetic Pathology.International journal of molecular sciences · 2020Article
- D1 Dopamine Receptor Activation Induces Neuronal eEF2 Pathway-Dependent Protein Synthesis.Frontiers in molecular neuroscience · 2020Article
- Local Inhibition of PERK Enhances Memory and Reverses Age-Related Deterioration of Cognitive and Neuronal Properties.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- PKR: A Kinase to Remember.Frontiers in molecular neuroscience · 2018Review
- Article
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Authors and funding
4 authors at 1 institution in 1 country.
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Abstract
Aging is the main risk factor for neurodegenerative diseases, including Alzheimer's disease (AD). However, evidence indicates that the pathological process begins long before actual cognitive or pathological symptoms are apparent. The long asymptomatic phase and complex integration between genetic, environmental and metabolic factors make it one of the most challenging diseases to understand and cure. In the present study, we asked whether an environmental factor such as high-fat (HF) diet would synergize with a genetic factor to affect the metabolic and cognitive state in the Apolipoprotein E (ApoE4) mouse model of AD. Our data suggest that a HF diet induces diabetes mellitus (DM)-like metabolism in ApoE4 mice, as well as changes in β-site amyloid precursor protein-cleaving enzyme 1 (BACE1) protein levels between the two ApoE strains. Furthermore, HF diet induces anxiety in this AD mouse model. Our results suggest that young ApoE4 carriers are prone to psychological stress and metabolic abnormalities related to AD, which can easily be triggered via HF nutrition.
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