ArticleFrontiers in neuroanatomy2016
Segmentation of the Cingulum Bundle in the Human Brain: A New Perspective Based on DSI Tractography and Fiber Dissection Study.
Article in Frontiers in neuroanatomy, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers, 2 of them syntheses that pooled it.
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Who cites it
71 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Disentangling in-vivo microstructural changes of white and gray matter in mild cognitive impairment and Alzheimer's disease: a systematic review and meta-analysis.Brain imaging and behavior · 2023Pooled it
- Unraveling the mystery of white matter in depression: A translational perspective on recent advances.Brain and behavior · 2022Pooled it
- Elucidation of the relationship between sensory processing and white matter using diffusion tensor imaging tractography in young adults.Scientific reports · 2021Trial
- Cingulum stimulation enhances positive affect and anxiolysis to facilitate awake craniotomy.The Journal of clinical investigation · 2019Trial
- Preoperative neuropsychological profiles in adult parietal glial and glioneuronal tumors: A retrospective descriptive study.Neurosurgical review · 2026Article
- Positive association between emotional intelligence and white matter integrity in the cingulum and superior longitudinal fasciculus in healthy Japanese adults.Brain structure & function · 2026Article
- White matter and impulsivity are prospectively associated with non‑suicidal self‑injury in youth: evidence for sex differences.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Microstructural Integrity of Hippocampal-Posterior Cortical White Matter Is Associated With Phenomenological Properties of Trauma-Related Intrusive Memories.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2026Article
- The Cortico-Cortical and Subcortical Circuits of the Human Brain Language Centers Including the Dual Limbic and Language Functioning Fiber Tracts.Brain sciences · 2026Review
- The modular nature of long-association pathways in the human brain.bioRxiv : the preprint server for biology · 2026Article
- Morphological variations and cortical atrophy of the precuneus in normal aging and Alzheimer's disease.Journal of anatomy · 2026Article
- White matter microstructure alterations from alcohol use disorder persist into early abstinence.Brain communications · 2026Article
- Dopamine and serotonin transients predict depressive symptom relief following deep brain stimulation of human subcallosal cingulate cortex.bioRxiv : the preprint server for biology · 2025Article
- White matter microstructure of the cingulum bundle and the uncinate fasciculus in primary and secondary callous-unemotional traits.European child & adolescent psychiatry · 2025Article
- Effect of combined transcranial direct current stimulation and cognitive training on brain microstructure and network homogeneity in late-life depression: a pilot study.Journal of affective disorders reports · 2025Article
- Asymmetric Cingulum Bundle Connectivity Is Modulated by Paracingulate Sulcus Morphology.Human brain mapping · 2025Article
- Connectivity related to major brain functions in Alzheimer disease progression: microstructural properties of the cingulum bundle and its subdivision using diffusion-weighted MRI.European radiology experimental · 2025Article
- From Circuits to Lifespan: Translating Mouse and Human Timelines with Neuroimaging-Based Tractography.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- White matter correlates of impulsive behavior in healthy individuals: A diffusion magnetic resonance imaging study.PCN reports : psychiatry and clinical neurosciences · 2024Article
- An inclusive anatomical network analysis of human craniocerebral topology.Journal of anatomy · 2024Article
11 more citing papers are in PubMed but not listed here.
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5 authors.
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Abstract
The cingulum bundle (CB) is a critical white matter fiber tract in the brain, which forms connections between the frontal lobe, parietal lobe and temporal lobe. In non-human primates, the CB is actually divided into distinct subcomponents on the basis of corticocortical connections. However, at present, no study has verified similar distinct subdivisions in the human brain. In this study, we reconstructed these distinct subdivisions in the human brain, and determined their exact cortical connections using high definition fiber tracking (HDFT) technique on 10 healthy adults and a 488-subject template from the Human Connectome Project (HCP-488). Fiber dissections were performed to verify tractography results. Five CB segments were identified. CB-I ran from the subrostral areas to the precuneus and splenium, encircling the corpus callosum (CC). CB-II arched around the splenium and extended anteriorly above the CC to the medial aspect of the superior frontal gyrus (SFG). CB-III connected the superior parietal lobule (SPL) and precuneus with the medial aspect of the SFG. CB-IV was a relatively minor subcomponent from the SPL and precuneus to the frontal region. CB-V, the para-hippocampal cingulum, stemmed from the medial temporal lobe and fanned out to the occipital lobes. Our findings not only provide a more accurate and detailed description on the associated architecture of the subcomponents within the CB, but also offer new insights into the functional role of the CB in the human brain.
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