ReviewCurrent colorectal cancer reports
Organoids as a Model for Colorectal Cancer.
Review in Current colorectal cancer reports. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed.
- Cloud-based ligand-guided virtual screening with deep-learning-enhanced docking identifies a micromolar CXCR4 antagonist.Molecular diversity · 2026Article
- The Evolution of Organoids: From Discovery to Cutting-Edge Applications.Stem cell reviews and reports · 2026Review
- Artificial Intelligence Virtual Organoids (AIVOs).Bioactive materials · 2026Review
- Article
- Mini-organs with big impact: Organoids in liver cancer studies.Oncology research · 2023Review
- Novel therapeutic diiminoquinone exhibits anticancer effects on human colorectal cancer cells in two-dimensional and three-dimensionalWorld journal of gastroenterology · 2022Article
- Assay establishment and validation of a high-throughput organoid-based drug screening platform.Stem cell research & therapy · 2022Article
- A Systematically Reduced Mathematical Model for Organoid Expansion.Frontiers in bioengineering and biotechnology · 2021Article
- Review
- Article
- Comparison of Cell and Organoid-Level Analysis of Patient-Derived 3D Organoids to Evaluate Tumor Cell Growth Dynamics and Drug Response.SLAS discovery : advancing life sciences R & D · 2020Article
- TatS: a novel in vitro tattooed human skin model for improved pigment toxicology research.Archives of toxicology · 2020Article
- A new aggressive xenograft model of human colon cancer using cancer-associated fibroblasts.PeerJ · 2020Article
- Carcinogenicity assessment: Addressing the challenges of cancer and chemicals in the environment.Environment international · 2019Review
- Stemness underpinning all steps of human colorectal cancer defines the core of effective therapeutic strategies.EBioMedicine · 2019Article
- Pyrin Inflammasome Regulates Tight Junction Integrity to Restrict Colitis and Tumorigenesis.Gastroenterology · 2018Article
- Nano- and Micro-Patterned S-, H-, and X-PDMS for Cell-Based Applications: Comparison of Wettability, Roughness, and Cell-Derived Parameters.Frontiers in bioengineering and biotechnology · 2018Article
- Organoid and Enteroid Modeling ofFrontiers in cellular and infection microbiology · 2018Review
- Immuno-fluorescent Labeling of Microtubules and Centrosomal Proteins in Ex Vivo Intestinal Tissue and 3D In Vitro Intestinal Organoids.Journal of visualized experiments : JoVE · 2017Article
- Single-cell functional and chemosensitive profiling of combinatorial colorectal therapy in zebrafish xenografts.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Modelling human diseases in in vitro systems is undisputedly an invaluable research tool, yet there are many limitations. Some of those limitations have been overcome through the introduction of organoid culture systems, which have revolutionised colorectal cancer research and enabled an array of new experimental techniques. This 3D system models the physiology, shape, dynamics and cell make-up of the intestinal epithelium producing a relevant and highly adaptable model system. The increased functional relevance of this model compared to the use of 2D cancer cell lines makes it an invaluable tool for both basic and translational research. As the limitations of this system are being overcome to make high-throughput assays possible, it is clear that organoids are becoming a mainstay of colorectal cancer research. This review aims to explore the advantages and limitations of this system and discusses the future directions enabled by this model.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.