Evidence map›Paper›PMID 27655966›Full record

ArticleJournal of neurophysiology2016

Physiology and anatomy of neurons in the medial superior olive of the mouse.

Matthew J Fischl, R Michael Burger, Myriam Schmidt-Pauly, Olga Alexandrova, James L Sinclair, Benedikt Grothe, Ian D Forsythe, Conny Kopp-Scheinpflug

Open access · hybridAbstract read
In one paragraph

Article in Journal of neurophysiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
3.2field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 38 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Across Species "Natural Ablation" Reveals the Brainstem Source of a Noninvasive Biomarker of Binaural Hearing.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018
    Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 3 countries.

Matthew J FischlDivision of Neurobiology, Department of Biology II, Ludwig Maximilian University Munich, Planegg-Martinsried, Germany.
R Michael BurgerDepartment of Biological Sciences, Lehigh University, Bethlehem, Pennsylvania; and.
Myriam Schmidt-PaulyDivision of Neurobiology, Department of Biology II, Ludwig Maximilian University Munich, Planegg-Martinsried, Germany.
Olga AlexandrovaDivision of Neurobiology, Department of Biology II, Ludwig Maximilian University Munich, Planegg-Martinsried, Germany.
James L SinclairDivision of Neurobiology, Department of Biology II, Ludwig Maximilian University Munich, Planegg-Martinsried, Germany.
Benedikt GrotheDivision of Neurobiology, Department of Biology II, Ludwig Maximilian University Munich, Planegg-Martinsried, Germany.
Ian D ForsytheDepartment of Neuroscience, Psychology, and Behaviour, University of Leicester, Leicester, United Kingdom.
Conny Kopp-ScheinpflugDivision of Neurobiology, Department of Biology II, Ludwig Maximilian University Munich, Planegg-Martinsried, Germany; cks@bio.lmu.de.
Ludwig-Maximilians-Universität München · DELehigh University · USUniversity of Leicester · GB

Funding

Medical Research Council MR/K005170/1
6 · The paper itself

Abstract

In mammals with good low-frequency hearing, the medial superior olive (MSO) computes sound location by comparing differences in the arrival time of a sound at each ear, called interaural time disparities (ITDs). Low-frequency sounds are not reflected by the head, and therefore level differences and spectral cues are minimal or absent, leaving ITDs as the only cue for sound localization. Although mammals with high-frequency hearing and small heads (e.g., bats, mice) barely experience ITDs, the MSO is still present in these animals. Yet, aside from studies in specialized bats, in which the MSO appears to serve functions other than ITD processing, it has not been studied in small mammals that do not hear low frequencies. Here we describe neurons in the mouse brain stem that share prominent anatomical, morphological, and physiological properties with the MSO in species known to use ITDs for sound localization. However, these neurons also deviate in some important aspects from the typical MSO, including a less refined arrangement of cell bodies, dendrites, and synaptic inputs. In vitro, the vast majority of neurons exhibited a single, onset action potential in response to suprathreshold depolarization. This spiking pattern is typical of MSO neurons in other species and is generated from a complement of K

Indexed as

Acoustic StimulationAction PotentialsAnimalsAnimals, NewbornAuditory PathwaysCholine O-AcetyltransferaseElectric StimulationGlycine Plasma Membrane Transport ProteinsIn Vitro TechniquesMiceMice, Inbred C57BLMicrotubule-Associated ProteinsModels, NeurologicalNeuronsPatch-Clamp TechniquesPhosphopyruvate Hydratase2-hydroxy-4,4'-diamidinostilbene, methanesulfonate saltCholine O-AcetyltransferaseGlycine Plasma Membrane Transport ProteinsMicrotubule-Associated ProteinsPhosphopyruvate HydrataseSlc6a5 protein, mouseStilbamidinesVesicular Glutamate Transport Protein 1auditory brain stemKv1Kv3medial superior olivemouse

Identifiers

PMID27655966
PMCPMC5133312
OpenAlexW2522460984

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.