Evidence map›Paper›PMID 27655963›Full record

ArticleJournal of neurophysiology2016

α7-nAChR agonist enhances neural plasticity in the hippocampus via a GABAergic circuit.

Matthew Townsend, Andrew Whyment, Jean-Sebastien Walczak, Ross Jeggo, Marco van den Top, Dorothy G Flood, Liza Leventhal, Holger Patzke, Gerhard Koenig

Open access · greenAbstract read
In one paragraph

Article in Journal of neurophysiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 28 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Review
  6. Review
  7. Article
  8. Significance of GABAInternational journal of molecular sciences · 2021
    Review
  9. Unbalanced Regulation of α7 nAChRs by Ly6h and NACHO Contributes to Neurotoxicity in Alzheimer's Disease.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021
    Article
  10. CaCells · 2020
    Review
  11. Review
  12. Temporal dynamics of learning-promoted synaptic diversity in CA1 pyramidal neurons.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019
    Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Therapeutics of Neurotransmitters in Alzheimer's Disease.Journal of Alzheimer's disease : JAD · 2017
    Review
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Matthew TownsendFORUM Pharmaceuticals, Inc., Waltham, Massachusetts; and matt.townsend@abbvie.com.
Andrew WhymentCerebrasol, Ltd., Montreal, Quebec City, Canada.
Jean-Sebastien WalczakCerebrasol, Ltd., Montreal, Quebec City, Canada.
Ross JeggoCerebrasol, Ltd., Montreal, Quebec City, Canada.
Marco van den TopCerebrasol, Ltd., Montreal, Quebec City, Canada.
Dorothy G FloodFORUM Pharmaceuticals, Inc., Waltham, Massachusetts; and.
Liza LeventhalFORUM Pharmaceuticals, Inc., Waltham, Massachusetts; and.
Holger PatzkeFORUM Pharmaceuticals, Inc., Waltham, Massachusetts; and.
Gerhard KoenigFORUM Pharmaceuticals, Inc., Waltham, Massachusetts; and.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Agonists of the α

Indexed as

Action Potentialsalpha7 Nicotinic Acetylcholine ReceptorAnimalsCholinesterase InhibitorsDonepezilEvoked PotentialsExcitatory Amino Acid AntagonistsFemaleGABA AgentsGABAergic NeuronsHippocampusHumansIndansInhibitory Postsynaptic PotentialsMaleNerve Net7-fluoro-N-quinuclidin-3-yl)benzo(b)thiophene-2-carboxamidealpha7 Nicotinic Acetylcholine ReceptorCholinesterase InhibitorsDonepezilExcitatory Amino Acid AntagonistsGABA AgentsIndansNicotinic AgonistsPiperidinesQuinuclidinesThiophenesAlzheimer's diseaseFRM-17848GABAA α5-receptorschizophreniaα7-nAChR

Identifiers

PMID27655963
PMCPMC5133305
OpenAlexW2521176850

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.