ArticleCerebral cortex (New York, N.Y. : 1991)2017
Anterior Cingulate Pathways May Affect Emotions Through Orbitofrontal Cortex.
Article in Cerebral cortex (New York, N.Y. : 1991), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
34 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.
- Human Pregenual Anterior Cingulate Cortex: Structural, Functional, and Connectional Heterogeneity.Cerebral cortex (New York, N.Y. : 1991) · 2019Pooled it
- Topographic Mesocortex-Amygdalar Projections Expand the Molecular and Functional Model of the Limbic System.Molecular neurobiology · 2026Article
- Internal connectivity of the mouse mesocortical ring and functional implications.Brain structure & function · 2026Article
- Neuroanatomical signatures of chronotype in young adults.Brain imaging and behavior · 2026Article
- From hidden springs to endless oceans: exploring the complementary roles of the amygdala and hippocampus in phenomenal experience.Neuroscience of consciousness · 2026Article
- Review
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- The Cortical Structural Model Extends to Thalamocortical Connections.The European journal of neuroscience · 2025Article
- Age and gender-related patterns of arterial transit time and cerebral blood flow in healthy adults.NeuroImage · 2025Article
- Efficacy of Transcranial Direct Current Stimulation (tDCS) on Neuropsychiatric Symptoms in Substance Use Disorder (SUD)-A Review and Insights into Possible Mechanisms of Action.Journal of clinical medicine · 2025Review
- The possibilities of conscious experience in light of the dual origin hypothesis of the neocortex.Neuroscience of consciousness · 2025Article
- Sensing, feeling and regulating: investigating the association of focal brain damage with voluntary respiratory and motor control.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Article
- Distinct resting-state functional connectivity of the anterior cingulate cortex subregions in first-episode schizophrenia.Brain imaging and behavior · 2024Article
- The Effectiveness of Mindfulness in the Treatment of Methamphetamine Addiction Symptoms: Does Neuroplasticity Play a Role?Brain sciences · 2024Review
- Homology of neocortical areas in rats and primates based on cortical type analysis: an update of the Hypothesis on the Dual Origin of the Neocortex.Brain structure & function · 2023Article
- Electrophysiological Markers of Fairness and Selfishness Revealed by a Combination of Dictator and Ultimatum Games.Frontiers in systems neuroscience · 2022Article
- Pathways for Contextual Memory: The Primate Hippocampal Pathway to Anterior Cingulate Cortex.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
- Migraine Is More Than Just Headache: Is the Link to Chronic Fatigue and Mood Disorders Simply Due to Shared Biological Systems?Frontiers in human neuroscience · 2021Review
- Grey Matter Loss at Different Stages of Cognitive Decline: A Role for the Thalamus in Developing Alzheimer's Disease.Journal of Alzheimer's disease : JAD · 2021Article
- Serial Prefrontal Pathways Are Positioned to Balance Cognition and Emotion in Primates.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The anterior cingulate cortex (ACC) and posterior orbitofrontal cortex (pOFC) are associated with emotional regulation. These regions are old in phylogeny and have widespread connections with eulaminate neocortices, intricately linking areas associated with emotion and cognition. The ACC and pOFC have distinct cortical and subcortical connections and are also interlinked, but the pattern of their connections-which may be used to infer the flow of information between them-is not well understood. Here we found that pathways from ACC area 32 innervated all pOFC areas with a significant proportion of large and efficient terminals, seen at the level of the system and the synapse. The pathway from area 32 targeted overwhelmingly elements of excitatory neurons in pOFC, with few postsynaptic sites found on presumed inhibitory neurons. Moreover, pathways from area 32 originated mostly in the upper layers and innervated preferentially the middle-deep layers of the least differentiated pOFC areas, in a pattern reminiscent of feedforward communication. Pathway terminations from area 32 overlapped in the deep layers of pOFC with output pathways that project to the thalamus and the amygdala, and may have cascading downstream effects on emotional and cognitive processes and their disruption in psychiatric disorders.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.