ArticleCerebral cortex (New York, N.Y. : 1991)2017
Molecularly Defined Subplate Neurons Project Both to Thalamocortical Recipient Layers and Thalamus.
Article in Cerebral cortex (New York, N.Y. : 1991), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 1 of them a synthesis that pooled it.
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Who cites it
48 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Changing subplate circuits: Early activity dependent circuit plasticity.Frontiers in cellular neuroscience · 2022Pooled it
- Most Early-Born Subplate Neurons Persist as Layer 6b Neurons in the Adult Mouse Neocortex.The Journal of comparative neurology · 2026Article
- SpNeigh: spatial neighborhood and differential expression analysis for high-resolution spatial transcriptomics.NAR genomics and bioinformatics · 2026Article
- 3d-OT: a deep geometry-aware framework for heterogeneous slices alignment of spatial multi-omics.Nature methods · 2026Article
- A consensus definition for deep layer 6 excitatory neurons in mouse somatosensory, visual, and motor cortex.Cell reports · 2025Article
- Charting the spatial transcriptome of the human cerebral cortex at single-cell resolution.Nature communications · 2025Article
- An orexin-sensitive subpopulation of layer 6 neurons regulates cortical excitability and anxiety behaviour.Translational psychiatry · 2025Article
- Translaminar synchronous neuronal activity is required for columnar synaptic strengthening in the mouse neocortex.Nature communications · 2025Article
- Chronic silencing of Drd1a-Cre+ neurons impairs dopaminergic-driven cortical activation.Frontiers in neuroanatomy · 2025Article
- High-Complexity Barcoded Rabies Virus for Scalable Circuit Mapping Using Single-Cell and Single-Nucleus Sequencing.bioRxiv : the preprint server for biology · 2024Article
- Synaptic plasticity in human thalamocortical assembloids.Cell reports · 2024Article
- Correlation between the number of interstitial neurons of the white matter and number of neurons within cortical layers: Histological analyses in postnatal macaque.The Journal of comparative neurology · 2024Article
- Synaptic plasticity in human thalamocortical assembloids.bioRxiv : the preprint server for biology · 2024Article
- Distinct distribution of subplate neuron subtypes between the sensory cortices during the early postnatal period.The Journal of comparative neurology · 2024Article
- Region and layer-specific expression of GABAFrontiers in cellular neuroscience · 2024Article
- Highly branched and complementary distributions of layer 5 and layer 6 auditory corticofugal axons in mouse.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Early retinal deprivation crossmodally alters nascent subplate circuits and activity in the auditory cortex during the precritical period.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Article
- Axonal connections between S1 barrel, M1, and S2 cortex in the newborn mouse.Frontiers in neuroanatomy · 2023Article
- Structure and function of neocortical layer 6b.Frontiers in cellular neuroscience · 2023Review
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4 authors.
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Abstract
In mammals, subplate neurons (SPNs) are among the first generated cortical neurons. While most SPNs exist only transiently during development, a number of SPNs persist among adult Layer 6b (L6b). During development, SPNs receive thalamic and intra-cortical input, and primarily project to Layer 4 (L4). SPNs are critical for the anatomical and functional development of thalamocortical connections and also pioneer corticothalamic projections. Since SPNs are heterogeneous, SPN subpopulations might serve different roles. Here, we investigate the connectivity of one subpopulation, complexin-3 (Cplx3)-positive SPNs (Cplx3-SPNs), in mouse whisker somatosensory (barrel) cortex (S1). We find that many Cplx3-SPNs survive into adulthood and become a subpopulation of L6b. Cplx3-SPNs axons project to thalamorecipient layers, that is, L4, 5a, and 1. The L4 projections are biased towards the septal regions between barrels in the second postnatal week. Thus, S1 Cplx3-SPN targets co-localize with the eventual projections of the medial posterior thalamic nucleus (POm). In addition to their cortical targets, Cplx3-SPNs also extend long-range axons to several thalamic nuclei, including POm. Thus, Cplx3-SPN/L6b neurons are associated with paralemniscal pathways and can potentially directly link thalamocortical and corticothalamic circuits. This suggests an additional key role for SPNs in the establishment and maintenance of thalamocortical processing.
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