Evidence map›Paper›PMID 27655833›Full record

ArticleCarcinogenesis2016

Novel Helicobacter species H.japonicum isolated from laboratory mice from Japan induces typhlocolitis and lower bowel carcinoma in C57BL/129 IL10-/- mice.

Zeli Shen, Yan Feng, Sureshkumar Muthupalani, Alexander Sheh, Lenzie E Cheaney, Christian A Kaufman, Guanyu Gong, Bruce J Paster, James G Fox

Open access · bronzeAbstract read
In one paragraph

Article in Carcinogenesis, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
3.5field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. A Tripartite Efflux System Affects Flagellum Stability inInternational journal of molecular sciences · 2022
    Article
  3. Article
  4. Oral and intestinal bacterial exotoxins: Potential linked to carcinogenesis.Progress in molecular biology and translational science · 2020
    Review
  5. Article
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Zeli ShenDivision of Comparative Medicine.
Yan FengDivision of Comparative Medicine.
Sureshkumar MuthupalaniDivision of Comparative Medicine.
Alexander ShehDivision of Comparative Medicine.
Lenzie E CheaneyDivision of Comparative Medicine.
Christian A KaufmanDivision of Comparative Medicine.
Guanyu GongDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA and.
Bruce J PasterThe Forsyth Institute, Cambridge, MA 02139, USA.
James G FoxDivision of Comparative Medicine, jgfox@mit.edu.
Massachusetts Institute of Technology · US

Funding

Biomedical Research Training for Veterinary ScientistsT32OD010978 · OD · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI FOX, JAMES G · 2012 to 2017
$2.2M
NIH HHS T32 OD010978
6 · The paper itself

Abstract

A novel Helicobacter species Helicobacter japonicum was isolated from the stomach and intestines of clinically normal mice received from three institutes from Japan. The novel Helicobacter sp. was microaerobic, grew at 37°C and 42°C, was catalase and oxidase positive, but urease negative. It is most closely related to the 16S rRNA gene of H.muridarum (98.6%); to the 23S rRNA gene of H.hepaticus (97.9%); to the hsp60 gene of H.typhlonius (87%). The novel Helicobacter sp. has in vitro cytolethal distending toxin (CDT) activity; its cdtB gene sequence has 83.8% identity with that of H.hepaticus The whole genome sequence of H.japonicum MIT 01-6451 has a 2.06-Mb genome length with a 37.5% G + C content. When the organism was inoculated into C57BL/129 IL10

Indexed as

AnimalsCarcinomaHelicobacterHelicobacter InfectionsInflammatory Bowel DiseasesInterferon-gammaInterleukin-10Interleukin-17IntestinesJapanMiceMice, Inbred C57BLMice, KnockoutNitric Oxide Synthase Type IITumor Necrosis Factor-alphaTyphlitisIFNG protein, mouseIl17a protein, mouseInterferon-gammaInterleukin-10Interleukin-17Nitric Oxide Synthase Type IINos2 protein, mouseTumor Necrosis Factor-alpha

Identifiers

PMID27655833
PMCPMC5137264
OpenAlexW2521827343

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.