ArticleOncotarget2016
Sodium fluoride induces apoptosis in cultured splenic lymphocytes from mice.
Article in Oncotarget, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 35 citations in OpenAlex.
- Amelioration of Fluoride Induced Toxicity by trans-Chalcone in Zebrafish Larvae and Its Gill Cell Line: An In Vivo and In Vitro Approach.Environmental toxicology · 2026Article
- Biological Effects of D-Penicillamine on Copper Sulfate-Induced Possible Damage in the Caudate Nucleus: Role of Apoptotic Genes Bax, Bcl2, and Bax-Bcl2 Ratio.Biological trace element research · 2026Article
- Retraction: Sodium fluoride induces apoptosis in mouse splenocytes by activating ROS-dependent NF-κB signaling.Oncotarget · 2026Article
- Progress in research on the role of fluoride in immune damage.Frontiers in immunology · 2024Review
- Fluoride-induced apoptosis in non-skeletal tissues of experimental animals: A systematic review and meta-analysis.Heliyon · 2023Review
- Recent advances in cellular effects of fluoride: an update on its signalling pathway and targeted therapeutic approaches.Molecular biology reports · 2021Review
- Cinnamon Extract and Probiotic Supplementation Alleviate Copper-Induced Nephrotoxicity via Modulating Oxidative Stress, Inflammation, and Apoptosis in Broiler Chickens.Animals : an open access journal from MDPI · 2021Article
- Copper Induces Oxidative Stress and Apoptosis in the Mouse Liver.Oxidative medicine and cellular longevity · 2020Article
- A mini review of fluoride-induced apoptotic pathways.Environmental science and pollution research international · 2018Review
- The mitochondrial pathway is involved in sodium fluoride (NaF)-induced renal apoptosis in mice.Toxicology research · 2018Article
- Article
- Sodium fluoride causes hepatocellular S-phase arrest by activating ATM-p53-p21 and ATR-Chk1-Cdc25A pathways in mice.Oncotarget · 2018Article
- Sodium fluoride induces apoptosis in mouse splenocytes by activating ROS-dependent NF-κB signaling.Oncotarget · 2017Article
- Selenium against lead-induced apoptosis in chicken nervous tissues via mitochondrial pathway.Oncotarget · 2017Article
- Sodium fluoride exposure exerts toxic effects on porcine oocyte maturation.Scientific reports · 2017Article
- Article
- Sodium fluoride induces renal inflammatory responses by activating NF-κB signaling pathway and reducing anti-inflammatory cytokine expression in mice.Oncotarget · 2017Article
- Cytological Assessments and Transcriptome Profiling Demonstrate that Evodiamine Inhibits Growth and Induces Apoptosis in a Renal Carcinoma Cell Line.Scientific reports · 2017Article
- Histopathological findings of renal tissue induced by oxidative stress due to different concentrations of fluoride.Oncotarget · 2017Article
- Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Though fluorine has been shown to induce apoptosis in immune organs in vivo, there has no report on fluoride-induced apoptosis in the cultured lymphocytes. Therefore, this study was conducted with objective of investigating apoptosis induced by sodium fluoride (NaF) and the mechanism behind that in the cultured splenic lymphocytes by flow cytometry, western blot and Hoechst 33258 staining. The splenic lymphocytes were isolated from 3 weeks old male ICR mice and exposed to NaF (0, 100, 200, and 400 μmol/L) in vitro for 24 and 48 h. When compared to control group, flow cytometry assay and Hoechst 33258 staining showed that NaF induced lymphocytes apoptosis, which was promoted by decrease of mitochondria transmembrane potential, up-regulation of Bax, Bak, Fas, FasL, caspase 9, caspase 8, caspase 7, caspase 6 and caspase 3 protein expression (P < 0.05 or P <0.01), and down-regulation of Bcl-2 and Bcl-xL protein expression (P <0.05 or P <0.01). The above-mentioned data suggested that NaF-induced apoptosis in splenic lymphocytes could be mediated by mitochondrial and death receptor pathways.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.