ArticleOncotarget2016
The clinicopathologic relevance and prognostic value of tumor deposits and the applicability of N1c category in rectal cancer with preoperative radiotherapy.
Article in Oncotarget, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- MRI-Based Differentiation of Tumor Deposits and Lymph Node Metastases in Rectal Cancer: A Systematic Review of Diagnostic Performance.Journal of clinical medicine · 2026Review
- Prognosis of Mesorectal Tumor Deposits in Patients with Rectal Cancer Treated with Neoadjuvant Chemoradiotherapy and Total Mesorectal Excision.Journal of gastrointestinal cancer · 2023Article
- Adverse impact of tumor deposits in lymph node negative rectal cancer - a national cohort study.International journal of colorectal disease · 2023Article
- Synchronous multiple primary cancers involving rectal cancer and pelvic classical hodgkin lymphoma: the first case report.Frontiers in oncology · 2023Article
- The Prognostic Value of Adjuvant Chemotherapy in Colon Cancer With Solitary Tumor Deposit.Frontiers in oncology · 2022Article
- Prognostic and staging value of tumor deposits in patients with rectal cancer after neoadjuvant chemoradiotherapy.Translational cancer research · 2021Article
- Prognostic value of tumor deposits in locally advanced rectal cancer: a retrospective study with propensity score matching.International journal of clinical oncology · 2021Article
- The prognostic significance of tumor deposits in patients with head and neck squamous cell carcinomas.Annals of translational medicine · 2021Article
- Utility of texture analysis on T2-weighted MR for differentiating tumor deposits from mesorectal nodes in rectal cancer patients, in a retrospective cohort.Abdominal radiology (New York) · 2021Article
- Computed Tomography-Based Radiomics for Preoperative Prediction of Tumor Deposits in Rectal Cancer.Frontiers in oncology · 2021Article
- Preoperative prediction of tumour deposits in rectal cancer by an artificial neural network-based US radiomics model.European radiology · 2020Article
- A Modified Pathological N Stage Including Status of Tumor Deposits in Colorectal Cancer With Nodal Metastasis.Frontiers in oncology · 2020Article
- Tumor-infiltrating lymphocytes in primary tumors of colorectal cancer and their metastases.Experimental and therapeutic medicine · 2019Article
- Tumor deposit indicates worse prognosis than metastatic lymph node in gastric cancer: a propensity score matching study.Annals of translational medicine · 2019Article
- Prognostic value of N1c in colorectal cancer: a large population-based study using propensity score matching.International journal of colorectal disease · 2019Article
- Poor prognostic and staging value of tumor deposit in locally advanced rectal cancer with neoadjuvant chemoradiotherapy.Cancer medicine · 2019Article
- Development and Validation of a Nomogram for Predicting Specific Mortality Risk After Surgery for Locally Advanced Rectal Cancer: Studies Based on SEER Database and External Validation Cohorts.Cancer control : journal of the Moffitt Cancer CenterArticle
- Newly recognized extratumoral features of colorectal cancer challenge the current tumor-node-metastasis staging system.Annals of gastroenterologyReview
Corrections and comments
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9 authors.
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Abstract
The clinicopathologic relevance and prognostic value of tumor deposits in colorectal cancer has been widely demonstrated. However, there are still debates in the prognostic value of tumor deposits and the applicability of N1c category in rectal cancer with preoperative radiotherapy. In this study, rectal cancer with preoperative radiotherapy followed by resection of primary tumors registered in Surveillance, Epidemiology and End Results (SEER) database from 2010-2012 were analyzed. There were 4,813 cases eligible for this study, and tumor deposits were found in 514 (10.7%) cases. The presence of tumor deposits was significantly associated with some aggressive characteristics, including poorer tumor differentiation, more advanced ypT category, ypN category and ypTNM stage, distant metastasis, elevated carcinoembryonic antigen, higher positive rates of circumferential resection margin and perineural invasion (all P < = 0.001). Tumor deposit was also an independent negative prognostic factor for cancer-specific survival in rectal cancer with preoperative radiotherapy (adjusted HR and 95% CI: 2.25 (1.51 - 3.35)). N1c category had significant worse survival compared with N0 category (adjusted HR and 95% CI: 2.41 (1.24 - 4.69)). In conclusion, tumor deposit was a significant and independent prognostic factor, and the N1c category by the 7th edition of AJCC/TNM staging system was applicable in rectal cancer with preoperative radiotherapy.
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