Evidence map›Paper›PMID 27655627›Full record

ArticleStem cell research & therapy2016

Repair of human periodontal bone defects by autologous grafting stem cells derived from inflammatory dental pulp tissues.

Ye Li, Shanmei Zhao, Xi Nan, Hong Wei, Jianfeng Shi, Ang Li, Jianzhong Gou

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stem cell research & therapy, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  6. Stem Cells and Bone Tissue Engineering.Life (Basel, Switzerland) · 2024
    Review
  7. Article
  8. Article
  9. Review
  10. Article
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  14. Dental pulp stem cells for reconstructing bone defects: A systematic review and meta-analysis.Journal of dental research, dental clinics, dental prospects · 2022
    Review
  15. Review
  16. Dental Pulp Stem Cell-Derived Secretome and Its Regenerative Potential.International journal of molecular sciences · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ye LiKey Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Shanmei ZhaoDepartment of Periodontology, College of Stomatology, Xi'an Jiaotong University, Xi Wu Road No. 98, Xi'an, Shaanxi, 710004, China.
Xi NanDepartment of Periodontology, College of Stomatology, Xi'an Jiaotong University, Xi Wu Road No. 98, Xi'an, Shaanxi, 710004, China.
Hong WeiKey Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Jianfeng ShiKey Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Ang LiKey Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University, Xi'an, Shaanxi, China. drliang@mail.xjtu.edu.cn.
Jianzhong GouDepartment of Periodontology, College of Stomatology, Xi'an Jiaotong University, Xi Wu Road No. 98, Xi'an, Shaanxi, 710004, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundRecently, stem cells derived from inflammatory dental pulp tissues (DPSCs-IPs) have demonstrated regenerative potential, but the real effect remains to be examined. This pilot study attempted to isolate DPSCs-IPs from two patients and to evaluate the feasibility and the effect of reconstructing periodontal intrabone defects in each patient.

methodsDPSCs-IPs were harvested from two patients with periodontal intrabone defects with their approval. After discussing the biological characteristics of DPSCs-IPs in each patient, DPSCs-IPs were loaded onto the scaffold material β-tricalcium phosphate and engrafted into the periodontal defect area in the root furcation. After 1, 3, and 9 months, the outcome was evaluated by clinical assessment and radiological study. Furthermore, new samples were collected and the biological characteristics of DPSCs-IPs were further studied compared with normal dental pulp stem cells. The primary cell culture success rate, cell viability, cell cycle analysis, and proliferation index were used to describe the growth state of DPSCs-IPs. In-vitro differentiation ability detection was used to further discuss the stem cell characteristics of DPSCs-IPs.

resultsAs expected, DPSCs-IPs were able to engraft and had an effect of regeneration of new bones to repair periodontal defects 9 months after surgical reconstruction. Although the success rate of primary cell culture and growth status was slightly inhibited, DPSCs-IPs expressed comparable levels of stem cell markers as well as retaining their multidifferentiation ability.

conclusionsWe developed a standard procedure that is potentially safe and technological for clinical periodontal treatment using human autologous DPSCs-IPs.

trial registrationAccording to the editorial policies, the present study is a purely observational study, so trial registration is not required.

Indexed as

Dental pulp stem cellInflamed pulpTissue regeneration

Identifiers

PMID27655627
PMCPMC5032237

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.