Evidence map›Paper›PMID 27655467›Full record

ArticleJournal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine2016

Obstructive Sleep-Disordered Breathing Is More Common than Central in Mild Familial Dysautonomia.

Max J Hilz, Sebastian Moeller, Susanne Buechner, Hanna Czarkowska, Indu Ayappa, Felicia B Axelrod, David M Rapoport

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. The Longest Obstructive Apnea You Have Ever Seen: A Patient With New-Onset Autonomic Dysfunction.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2018
    Article
  3. Article
  4. Sleep Apnea in Familial Dysautonomia: A Reflection of Apnea Pathogenesis.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2016
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 4 countries.

Max J HilzDepartment of Neurology, University of Erlangen-Nürnberg, Erlangen, Germany.
Sebastian MoellerDepartment of Neurology, University of Erlangen-Nürnberg, Erlangen, Germany.
Susanne BuechnerDepartment of Neurology, General Hospital of Bozen/Bolzano, Bozen/Bolzano, Italy.
Hanna CzarkowskaCushing Neuroscience Institute, NS-LIJ Health System, Great Neck, NY.
Indu AyappaDivision of Pulmonary, Critical Care and Sleep Medicine, New York University School of Medicine, New York, NY.
Felicia B AxelrodDysautonomia Center, New York University Langone School of Medicine, New York, NY.
David M RapoportDivision of Pulmonary, Critical Care and Sleep Medicine, New York University School of Medicine, New York, NY.
New York University · USFriedrich-Alexander-Universität Erlangen-Nürnberg · DENeurosciences Institute · USOspedale di Bolzano · ITUniversity College London · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

STUDY

objectivesIn familial dysautonomia (FD) patients, sleep-disordered breathing (SDB) might contribute to their high risk of sleep-related sudden death. Prevalence of central versus obstructive sleep apneas is controversial but may be therapeutically relevant. We, therefore, assessed sleep structure and SDB in FD-patients with no history of SDB.

methods11 mildly affected FD-patients (28 ± 11 years) without clinically overt SDB and 13 controls (28 ± 10 years) underwent polysomnographic recording during one night. We assessed sleep stages, obstructive and central apneas (≥ 90% air flow reduction) and hypopneas (> 30% decrease in airflow with ≥ 4% oxygen-desaturation), and determined obstructive (oAI) and central (cAI) apnea indices and the hypopnea index (HI) as count of respective apneas/hypopneas divided by sleep time. We obtained the apnea-hypopnea index (AHI4%) from the total of apneas and hypopneas divided by sleep time. We determined differences between FD-patients and controls using the U-test and within-group differences between oAIs, cAIs, and HIs using the Friedman test and Wilcoxon test.

resultsSleep structure was similar in FD-patients and controls. AHI4% and HI were significantly higher in patients than controls. In patients, HIs were higher than oAIs and oAIs were higher than cAIs. In controls, there was no difference between HIs, oAIs, and cAIs. Only patients had apneas and hypopneas during slow wave sleep.

conclusionsIn our FD-patients, obstructive apneas were more common than central apneas. These findings may be related to FD-specific pathophysiology. The potential ramifications of SDB in FD-patients suggest the utility of polysomnography to unveil SDB and initiate treatment. COMMENTARY: A commentary on this article appears in this issue on page 1583.

Indexed as

AdolescentAdultDysautonomia, FamilialFemaleHumansMaleMiddle AgedPolysomnographySleep Apnea, CentralSleep Apnea, ObstructiveYoung Adultfamilial dysautonomiahereditary sensory and autonomic neuropathy type IIIobstructive sleep apneasleep-disordered breathing

Identifiers

PMID27655467
PMCPMC5155190
OpenAlexW2527797172

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.