ArticleJournal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine2017
Increased Mortality in Relation to Insomnia and Obstructive Sleep Apnea in Korean Patients Studied with Nocturnal Polysomnography.
Article in Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.
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Who cites it
14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 31 citations in OpenAlex.
- Incidence of adverse cardiovascular events in patients with insomnia: A systematic review and meta-analysis of real-world data.PloS one · 2023Pooled it
- Sudden death in individuals with obstructive sleep apnoea: a systematic review and meta-analysis.BMJ open respiratory research · 2021Pooled it
- Effect of lung function on the apnea-hypopnea index in patients with overlap syndrome: a multicenter cross-sectional study.Sleep & breathing = Schlaf & Atmung · 2020Trial
- Insomnia and Cardiovascular Disease: Untangling a Complex Relationship.Journal of sleep research · 2026Review
- Polysomnographic findings and psychiatric symptoms in patients with comorbid insomnia and sleep apnea: a retrospective study focusing on sex differences.Sleep & breathing = Schlaf & Atmung · 2025Article
- Insomnia symptoms and increased risk of all-cause mortality by age and sex.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2024Article
- Assessment of cephalometric parameters and correlation with the severity of the obstructive sleep apnea syndrome.Journal of translational medicine · 2024Observational
- Sleep difficulties, incident dementia and all-cause mortality among older adults across 8 years: Findings from the National Health and Aging Trends Study.Journal of sleep research · 2021Article
- Prevalence of Insomnia in an Oncology Patient Population: An Irish Tertiary Referral Center Experience.Journal of the National Comprehensive Cancer Network : JNCCN · 2020Article
- Insomnia Disorder Increases the Risk of Mortality: Pooled Analysis of Annual Cumulative Time-to-Event Data.The Psychiatric quarterly · 2020Article
- The Prevalence and Incidence of Insomnia in Korea during 2005 to 2013.Psychiatry investigation · 2020Article
- Insomnia is associated with increased mortality in patients with first-ever stroke: a 6-year follow-up in a Chinese cohort study.Stroke and vascular neurology · 2018Article
- Smartphone applications for sleep tracking: rating and perceptions about behavioral change among users.Sleep science (Sao Paulo, Brazil)Article
- Craniofacial morphology in patients with obstructive sleep apnea: cephalometric evaluation.Brazilian journal of otorhinolaryngologyArticle
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
STUDY
objectivesTo elucidate the links between the two most prevalent sleep disorders, insomnia and obstructive sleep apnea (OSA), and mortality.
methodsWe studied 4,225 subjects who were referred to the Center for Sleep and Chronobiology, Seoul National University Hospital, from January 1994 to December 2008. We divided the subjects into five groups: mild OSA (5 ≤ AHI < 15), moderate OSA (15 ≤ AHI < 30), severe OSA (AHI ≥ 30), insomnia, and a no-sleep-disorder group consisting of subjects without sleep disorders. Standardized mortality ratio (SMR), hazard ratio, and the survival rates of the five groups were calculated and evaluated.
resultsThe SMR of all-cause mortality was significantly higher in the severe OSA group than in the general population (1.52, 95% CI 1.23-1.85, p < 0.05). The SMR of cardiovascular mortality increased progressively with the severity of OSA (no-sleep-disorder: 0.09, mild: 0.40, moderate: 0.52, severe: 1.79, p < 0.05). Statistical analyses of the hazard ratios indicated that severe OSA is a risk factor for all-cause mortality (HR 3.50, 95% CI 1.03-11.91, p = 0.045) and cardiovascular mortality (HR 17.16, 95% CI 2.29-128.83, p = 0.006). Cardiovascular mortality was also significantly elevated in the insomnia group (HR 8.11, 95% CI 1.03-63.58, p = 0.046).
conclusionsSevere OSA was associated with increased all-cause mortality and cardiovascular mortality compared to the no-sleep-disorder group. Insomnia was associated with increased cardiovascular mortality compared to the no-sleep-disorder group.
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