ArticleJournal of materials science. Materials in medicine2016
Experimental wound dressings of degradable PHA for skin defect repair.
Article in Journal of materials science. Materials in medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 96 citations in OpenAlex.
- From Waste to Treasure: Therapeutic Horizons of Polyhydroxyalkanoates in Modern Medicine.Pharmaceutics · 2026Review
- Life cycle design of polyhydroxyalkanoates (PHA).National science review · 2025Review
- Self-Reinforced Biocomposites Made from Poly(3-hydroxybutyrate-ACS omega · 2024Article
- Haloarchaeal poly[(3-hydroxybutyrate)-RSC advances · 2024Article
- Review
- Influence of Rheological and Morphological Characteristics of Polyhydroxybutyrate on Its Meltblown Process Behavior.Materials (Basel, Switzerland) · 2023Article
- Review
- Article
- Biodegradable Electrospun Scaffolds as an Emerging Tool for Skin Wound Regeneration: A Comprehensive Review.Pharmaceuticals (Basel, Switzerland) · 2023Review
- Additive Manufacturing of Polyhydroxyalkanoate-Based Blends Using Fused Deposition Modelling for the Development of Biomedical Devices.Journal of functional biomaterials · 2023Article
- Resorbable Nanomatrices from Microbial Polyhydroxyalkanoates: Design Strategy and Characterization.Nanomaterials (Basel, Switzerland) · 2022Article
- Review
- Electrospun porous poly(3-hydroxybutyrate-RSC advances · 2022Article
- Review
- Recent progress in nanocomposites of carbon dioxide fixation derived reproducible biomedical polymers.Frontiers in chemistry · 2022Review
- Article
- From Residues to Added-Value Bacterial Biopolymers as Nanomaterials for Biomedical Applications.Nanomaterials (Basel, Switzerland) · 2021Review
- Synergistic Effect of Biomaterial and Stem Cell for Skin Tissue Engineering in Cutaneous Wound Healing: A Concise Review.Polymers · 2021Review
- Biomedical Applications of Bacteria-Derived Polymers.Polymers · 2021Review
- Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The present study reports construction of wound dressing materials from degradable natural polymers such as hydroxy derivatives of carboxylic acids (PHAs) and 3-hydroxybutyrate/4-hydroxybutyrate [P(3HB/4HB)] as copolymer. The developed polymer films and electrospun membranes were evaluated for its wound healing properties with Grafts-elastic nonwoven membranes carrying fibroblast cells derived from adipose tissue multipotent mesenchymal stem cells. The efficacy of nonwoven membranes of P(3HB/4HB) carrying the culture of allogenic fibroblasts was assessed against model skin defects in Wistar rats. The morphological, histological and molecular studies revealed the presence of fibroblasts on dressing materials which facilitated wound healing, vascularization and regeneration. Further it was also observed that cells secreted extracellular matrix proteins which formed a layer on the surface of membranes and promoted the migration of epidermal cells from the neighboring tissues surrounding the wound. The wounds under the P(3HB/4HB) membrane carrying cells healed 1.4 times faster than the wounds under the cell-free membrane and 3.5 times faster than the wounds healing under the eschar (control).The complete wound healing process was achieved at Day 14. Thus the study highlights the importance of nonwoven membranes developed from degradable P(3HB/4HB) polymers in reducing inflammation, enhancing angiogenic properties of skin and facilitating better wound healing process.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.