Evidence map›Paper›PMID 27655348›Full record

ArticleToxicological sciences : an official journal of the Society of Toxicology2017

An Extended Structure-Activity Relationship of Nondioxin-Like PCBs Evaluates and Supports Modeling Predictions and Identifies Picomolar Potency of PCB 202 Towards Ryanodine Receptors.

Erika B Holland, Wei Feng, Jing Zheng, Yao Dong, Xueshu Li, Hans-Joachim Lehmler, Isaac N Pessah

Open access · bronzeAbstract read
In one paragraph

Article in Toxicological sciences : an official journal of the Society of Toxicology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
3.4field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 44 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Gene×environment interactions in autism spectrum disorders.Current topics in developmental biology · 2023
    Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Marine and Anthropogenic Bromopyrroles Alter Cellular CaEnvironmental science & technology · 2021
    Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 3 countries.

Erika B HollandDepartment of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, California; erika.holland@csulb.edu.
Wei FengDepartment of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, California.
Jing ZhengDepartment of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, California.
Yao DongDepartment of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, California.
Xueshu LiDepartment of Occupational and Environmental Health, College of Public Health, University of Iowa, Iowa City, Iowa.
Hans-Joachim LehmlerDepartment of Occupational and Environmental Health, College of Public Health, University of Iowa, Iowa City, Iowa.
Isaac N PessahDepartment of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, California.
University of California, Davis · USCalifornia State University, Long Beach · USCenter for Children · USEnvironmental Health · GBUniversity of Iowa · US

Funding

Training CoreP42ES013661 · NIEHS · UNIVERSITY OF IOWA · PI Rachel Frances Marek · 2006 to 2026
$60.3M
Workshop on Environmental Technology Transfer and EntrepreneurshipP42ES004699 · NIEHS · UNIVERSITY OF CALIFORNIA DAVIS · PI HAMMOCK, BRUCE D · 1987 to 2021
$50.1M
Pulmonary Toxicology Facility CoreP30ES005605 · NIEHS · UNIVERSITY OF IOWA · PI Jong Sung Kim · 1990 to 2026
$40.5M
UC Davis Center for Children's Environmental Health (CCEH)P01ES011269 · NIEHS · UNIVERSITY OF CALIFORNIA DAVIS · PI VAN DE WATER, JUDY A. · 2001 to 2018
$12.5M
Molecular and Cellular Basis of PCB Developmental Neurotoxicity: ViCTER supplementR01ES014901 · NIEHS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI HANS-JOACHIM LEHMLER, Pamela J Lein · 2009 to 2026
$9.3M
Rodent Behavior CoreU54HD079125 · NICHD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI ABBEDUTO, LEONARD J. · 2013 to 2019
$8.5M
Training Program In Basic & Translational Cardiovascular ScienceT32HL086350 · NHLBI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Martin Cadeiras, David A. Liem · 2008 to 2026
$7.1M
Enantioselective Metabolism Influences PCB Developmental NeurotoxicityR01ES017425 · NIEHS · UNIVERSITY OF IOWA · PI LEHMLER, HANS-JOACHIM, LEIN, PAMELA J · 2010 to 2014
$2.0M
NHLBI NIH HHS T32 HL086350NICHD NIH HHS U54 HD079125NIEHS NIH HHS P01 ES011269NIEHS NIH HHS P30 ES005605NIEHS NIH HHS P42 ES004699NIEHS NIH HHS P42 ES013661NIEHS NIH HHS R01 ES014901NIEHS NIH HHS R01 ES017425
6 · The paper itself

Abstract

Nondioxin-like polychlorinated biphenyls (NDL PCBs) activate ryanodine-sensitive Ca

Indexed as

Models, TheoreticalAnimalsDose-Response Relationship, DrugPolychlorinated BiphenylsRadioligand AssayRyanodine Receptor Calcium Release ChannelStructure-Activity RelationshipTritiumPolychlorinated BiphenylsRyanodine Receptor Calcium Release ChannelTritiumneurotoxicity.nondioxin-like PCBsryanodine receptorsingle-channel gating

Identifiers

PMID27655348
PMCPMC5216651
OpenAlexW2521250091

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.