ArticleEuropean radiology2017
MRI shows thickening and altered diffusion in the median and ulnar nerves in multifocal motor neuropathy.
Article in European radiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.
- Meta-analysis of the normal diffusion tensor imaging values of the peripheral nerves in the upper limb.Scientific reports · 2023Pooled it
- High Resolution 3-T Magnetic Resonance Tractography Cannot Localise Conduction Block in Multifocal Motor Neuropathy With Conduction Block.Journal of the peripheral nervous system : JPNS · 2026Article
- Diffusion-Weighted Imaging in the Musculoskeletal System: Evolving Role in Modern Imaging Practice.Diagnostics (Basel, Switzerland) · 2026Review
- Diffusion tractography outside the brain: the road less travelled.Brain structure & function · 2026Review
- Multifocal Motor Neuropathy: A Narrative Review.Muscle & nerve · 2025Review
- Review
- Implantable, Bioresorbable Radio Frequency Resonant Circuits for Magnetic Resonance Imaging.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Review
- Quantitative MR Neurography in Multifocal Motor Neuropathy and Amyotrophic Lateral Sclerosis.Diagnostics (Basel, Switzerland) · 2023Article
- Quantitative magnetic resonance imaging of the brachial plexus shows specific changes in nerve architecture in chronic inflammatory demyelinating polyneuropathy, multifocal motor neuropathy and motor neuron disease.European journal of neurology · 2021Article
- MRI of the ulnar nerve pre- and post-transposition: imaging features and rater agreement.Skeletal radiology · 2021Article
- Mapping the rest of the human connectome: Atlasing the spinal cord and peripheral nervous system.NeuroImage · 2021Review
- Peripheral Nerve Diffusion Tensor Imaging : Interreader and Test-retest Reliability as Quantified by the Standard Error of Measurement.Clinical neuroradiology · 2020Article
- Peripheral Nerve Imaging Aids in the Diagnosis of Immune-Mediated Neuropathies-A Case Series.Diagnostics (Basel, Switzerland) · 2020Article
- Neuropathy associated with immunoglobulin M monoclonal gammopathy: A combined sonographic and nerve conduction study.Muscle & nerve · 2019Article
- Prevalence of fascicular hyperintensities in peripheral nerves of healthy individuals with regard to cerebral white matter lesions.European radiology · 2019Article
- Magnetic resonance imaging of the cervical spinal cord in spinal muscular atrophy.NeuroImage. Clinical · 2019Article
- Conduction Block and Nerve Cross-Sectional Area in Multifocal Motor Neuropathy.Frontiers in neurology · 2019Article
- Multifocal motor neuropathy in Austria: a nationwide survey of clinical features and response to treatment.Journal of neurology · 2018Article
- Feasibility of quantitative ultrashort echo time (UTE)-based methods for MRI of peripheral nerve.NMR in biomedicine · 2018Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
Abstract
objectivesTo study disease mechanisms in multifocal motor neuropathy (MMN) with magnetic resonance imaging (MRI) and diffusion tensor imaging (DTI) of the median and ulnar nerves.
methodsWe enrolled ten MMN patients, ten patients with amyotrophic lateral sclerosis (ALS) and ten healthy controls (HCs). Patients underwent MRI (in a prone position) and nerve conduction studies. DTI and fat-suppressed T2-weighted scans of the forearms were performed on a 3.0T MRI scanner. Fibre tractography of the median and ulnar nerves was performed to extract diffusion parameters: fractional anisotropy (FA), mean (MD), axial (AD) and radial (RD) diffusivity. Cross-sectional areas (CSA) were measured on T2-weighted scans.
resultsForty-five out of 60 arms were included in the analysis. AD was significantly lower in MMN patients (2.20 ± 0.12 × 10
conclusionsThickening of nerves is compatible with changes in the myelin sheath structure, whereas lowered AD values suggest axonal dysfunction. These findings suggest that myelin and axons are diffusely involved in MMN pathogenesis. KEY POINTS: • Diffusion magnetic resonance imaging provides quantitative information about multifocal motor neuropathy (MMN). • Diffusion tensor imaging allows non-invasive evaluation of the forearm nerves in MMN. • Nerve thickening and lowered diffusion parameters suggests myelin and axonal changes. • This study can help to provide insight into pathological mechanisms of MMN.
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Registered trials
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