Evidence map›Paper›PMID 27655030›Full record

ArticleCellular and molecular neurobiology2017

Suppressor of Cytokine Signalling 2 (SOCS2) Regulates Numbers of Mature Newborn Adult Hippocampal Neurons and Their Dendritic Spine Maturation.

Harleen S Basrai, Alisa Turbic, Kimberly J Christie, Ann M Turnley

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cellular and molecular neurobiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.3field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
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  4. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Harleen S BasraiDepartment of Anatomy and Neuroscience, The University of Melbourne, Parkville, VIC, 3010, Australia.
Alisa TurbicDepartment of Anatomy and Neuroscience, The University of Melbourne, Parkville, VIC, 3010, Australia.
Kimberly J ChristieDepartment of Anatomy and Neuroscience, The University of Melbourne, Parkville, VIC, 3010, Australia.
Ann M TurnleyDepartment of Anatomy and Neuroscience, The University of Melbourne, Parkville, VIC, 3010, Australia. turnley@unimelb.edu.au.
University of Melbourne · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Overexpression of suppressor of cytokine signalling 2 (SOCS2) has been shown to promote hippocampal neurogenesis in vivo and promote neurite outgrowth of neurons in vitro. In the adult mouse brain, SOCS2 is most highly expressed in the hippocampal CA3 region and at lower levels in the dentate gyrus, an expression pattern that suggests a role in adult neurogenesis. Herein we examine generation of neuroblasts and their maturation into more mature neurons in SOCS2 null (SOCS2KO) mice. EdU was administered for 7 days to label proliferative neural precursor cells. The number of EdU-labelled doublecortin

Indexed as

Cell DifferentiationNeurogenesisAgingAnimalsAnimals, NewbornCell SurvivalDendritic SpinesDentate GyrusDeoxyuridineHippocampusMice, Inbred C57BLMice, KnockoutSuppressor of Cytokine Signaling Proteins5-ethynyl-2'-deoxyuridineDeoxyuridineSocs2 protein, mouseSuppressor of Cytokine Signaling ProteinsCA3DendriteDentate gyrusNestinNeural precursor cell

Identifiers

PMID27655030
PMCPMC11482086
OpenAlexW2523062190

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.