Evidence map›Paper›PMID 27654882›Full record

Trial reportPediatric obesity2018

A pilot study of the effects of niacin administration on free fatty acid and growth hormone concentrations in children with obesity.

O A Galescu, M K Crocker, A M Altschul, S E Marwitz, S M Brady, J A Yanovski

Registry-linked trialAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Pediatric obesity, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It reports registered trial NCT01237041. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.7field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01237041 phase1 / phase2terminated

Free Fatty Acids, Body Weight, and Growth Hormone Secretion in Children

Ran2011Enrolled37Registered outcomes4Posted comparisons4ConditionsGrowth Hormone Deficiency, Obesity, Short StatureArmsDose-Establishing Study 1 Niacin 250mg, Dose-Establishing Study 1 Niacin 500mg, Dose-Establishing Study 2 Niacin 500mg, Niacin First, Placebo First
PMID 16912138PMID 9024217PMID 18782877other papers from this trial
Open the trial in the graph
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 18 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Association study between growth hormone receptor (Journal of exercise rehabilitation · 2016
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

O A GalescuSection on Growth and Obesity, Program in Developmental Endocrinology and Genetics, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), Bethesda, USA.
M K CrockerSection on Growth and Obesity, Program in Developmental Endocrinology and Genetics, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), Bethesda, USA.
A M AltschulSection on Growth and Obesity, Program in Developmental Endocrinology and Genetics, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), Bethesda, USA.
S E MarwitzSection on Growth and Obesity, Program in Developmental Endocrinology and Genetics, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), Bethesda, USA.
S M BradySection on Growth and Obesity, Program in Developmental Endocrinology and Genetics, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), Bethesda, USA.
J A YanovskiSection on Growth and Obesity, Program in Developmental Endocrinology and Genetics, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), Bethesda, USA.
Eunice Kennedy Shriver National Institute of Child Health and Human Development · USBoston University · US

Funding

Physiology, Psychology, and Genetics of ObesityZIAHD000641 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI YANOVSKI, JACK A. · 2009 to 2025
$24.8M
Physiology, Psychology, and Genetics of ObesityZ01HD000641 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI YANOVSKI, JACK A. · 1996 to 2008
$4.6M
Intramural NIH HHS Z01 HD000641Intramural NIH HHS Z99 HD999999Intramural NIH HHS ZIA HD000641
6 · The paper itself

Abstract

contextChildren with obesity have low spontaneous growth hormone (GH) secretion. High circulating free fatty acid (FFA) concentration is believed to inhibit GH secretion in those with obesity. In adults, lipolytic inhibition with niacin lowers FFA and increases GH, but there are no prior studies in children with obesity.

objectiveThe objective of the study was to determine the dose and frequency of niacin administration required to lower FFA and stimulate GH in children with obesity.

designDose-finding study of nondiabetic children ages 6-12 years with body mass index (BMI) ≥ 95th percentile given niacin 250 mg q2h × 3 doses (n = 2), 500 mg q2h × 3 doses (n = 5) or 500 mg q1h × 4 doses (n = 5).

participantsEight boys and four girls (age 9.7 ± 1.8 years; BMI 26.4 ± 3.1 kg m MAIN OUTCOME: Percentage of serum FFA values that were below 0.2 mEq L

resultsFFA decreased as the dose and frequency of niacin increased (p = .01). Niacin 500 mg q1h 4 doses suppressed FFA < 0.2 mEq L

conclusionsNiacin 500 mg q1h significantly lowered serum FFA and increased GH. These pilot data suggest that high FFA is an important suppressor of GH secretion in children with obesity.

Indexed as

Blood GlucoseBody Mass IndexChildFatty Acids, NonesterifiedFemaleGrowth HormoneHumansInsulinLipolysisMaleNiacinPediatric ObesityPilot ProjectsTreatment OutcomeBlood GlucoseFatty Acids, NonesterifiedGrowth HormoneInsulinNiacinadipose tissuefree fatty acidsgrowth hormonelipolysisobesitysomatotropin

Identifiers

PMID27654882
PMCPMC5360541
OpenAlexW2529451339

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.