ArticleHuman brain mapping2017
Relationship between structural and functional connectivity change across the adult lifespan: A longitudinal investigation.
Article in Human brain mapping, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers.
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Who cites it
70 citing papers in PubMed.
- Depression: higher temporal variability of the functional connectivity of the ventromedial prefrontal cortex and hippocampal system.NeuroImage. Clinical · 2026Article
- Deep brain stimulation induces white matter remodeling and functional changes to brain-wide networks.Nature neuroscience · 2026Article
- Structural and molecular determinants of medial temporal lobe network vulnerability in aging and Alzheimer's disease.Alzheimer's research & therapy · 2026Article
- Structure-function dynamics in healthy cognitive aging: a graph signal processing approach.Brain structure & function · 2026Article
- Structural and functional neuroimaging correlates of suicidal ideation in treatment-resistant major depressive disorder.The international journal of neuropsychopharmacology · 2026Article
- Functional and structural connectome-based predictive modelling of balance in elderly adults.Scientific reports · 2026Article
- Distinct functional networks derived from human induced pluripotent stem cell neuronal activity.Scientific reports · 2026Article
- The effective connectome over a century of human life.Communications biology · 2025Article
- White matter structure-function coupling alteration is associated with plasma biomarkers and cognition in Alzheimer's disease.European radiology · 2025Article
- Increased frontal functional connectivity correlates with structural disconnection in the anterior corpus callosum in healthy older adults.Scientific reports · 2025Article
- Functional and Structural Neural Plasticity Following sEMG Control of a Virtual Prosthetic Hand in an Individual with Bilateral Upper-Limb Congenital Amputation.Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference · 2025Article
- Review
- Neurocognitive correlates of cerebral mitochondrial function and energy metabolism using phosphorus magnetic resonance spectroscopy in older adults.GeroScience · 2025Article
- Human lifespan changes in the brain's functional connectome.Nature neuroscience · 2025Article
- Longitudinal excitation-inhibition balance altered by sex and APOE-ε4.Communications biology · 2025Article
- High-resolution structural connectivity mediates age-related differences in functional connectivity and fluid cognition.Brain communications · 2025Article
- Healthy Cognitive Aging Through Movement: A Practical Approach of Light-Intensity Aerobic Dance for Older Adults.Advances in neurobiology · 2025Review
- Audiovisual integration and whole-brain networks in preterm and full-term neonates: A two-layer multiplex network perspective on structural and functional connectivity.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- DFC-Igloo: A dynamic functional connectome learning framework for identifying neurodevelopmental biomarkers in very preterm infants.Computer methods and programs in biomedicine · 2024Article
- Age-related differences in resting-state, task-related, and structural brain connectivity: graph theoretical analyses and visual search performance.Brain structure & function · 2024Article
10 more citing papers are in PubMed but not listed here.
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7 authors.
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Abstract
Extensive efforts are devoted to understand the functional (FC) and structural connections (SC) of the brain. FC is usually measured by functional magnetic resonance imaging (fMRI), and conceptualized as degree of synchronicity in brain activity between different regions. SC is typically indexed by measures of white matter (WM) properties, for example, by diffusion weighted imaging (DWI). FC and SC are intrinsically related, in that coordination of activity across regions ultimately depends on fast and efficient transfer of information made possible by structural connections. Convergence between FC and SC has been shown for specific networks, especially the default mode network (DMN). However, it is not known to what degree FC is constrained by major WM tracts and whether FC and SC change together over time. Here, 120 participants (20-85 years) were tested at two time points, separated by 3.3 years. Resting-state fMRI was used to measure FC, and DWI to measure WM microstructure as an index of SC. TRACULA, part of FreeSurfer, was used for automated tractography of 18 major WM tracts. Cortical regions with tight structural couplings defined by tractography were only weakly related at the functional level. Certain regions of the DMN showed a modest relationship between change in FC and SC, but for the most part, the two measures changed independently. The main conclusions are that anatomical alignment of SC and FC seems restricted to specific networks and tracts, and that changes in SC and FC are not necessarily strongly correlated. Hum Brain Mapp 38:561-573, 2017. © 2016 Wiley Periodicals, Inc.
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