ArticleAddiction biology2017
A hypo-status in drug-dependent brain revealed by multi-modal MRI.
Article in Addiction biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 34 citations in OpenAlex.
- Resting-State Brain Entropy Reveals Altered Neural Dynamics and Cognitive Associations in Mild Traumatic Brain Injury: A Longitudinal Study.Journal of neuroscience research · 2026Article
- Uncovering phenotypic diversity and cell-type-specific prefrontal cortex calcium dynamics in rat fentanyl self-administration.bioRxiv : the preprint server for biology · 2026Article
- MUSIC: Multi-coil unified sparsity regularization using inter-slice correlation for arterial spin labeling MRI denoising.Pattern recognition letters · 2026Article
- Brain entropy as a biomarker of major depression in adolescents and young adults: insights from multimodal resting-state functional magentic resonance imaging.Psychoradiology · 2026Article
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- rsfMRI-based brain entropy is negatively correlated with gray matter volume and surface area.Brain structure & function · 2025Article
- Resting state fMRI-based temporal coherence mapping.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Older is order: entropy reduction in cortical spontaneous activity marks healthy aging.BMC neuroscience · 2024Article
- Altered Structural Connectivity and Functional Brain Dynamics in Individuals With Heavy Alcohol Use Elucidated via Network Control Theory.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2024Article
- Divergent association between pain intensity and resting-state fMRI-based brain entropy in different age groups.Journal of neuroscience research · 2024Article
- Task-induced changes in brain entropy.Journal of neuroscience research · 2024Article
- Common hyper-entropy patterns identified in nicotine smoking, marijuana use, and alcohol use based on uni-drug dependence cohorts.Medical & biological engineering & computing · 2023Article
- Task-induced changes in brain entropy.medRxiv : the preprint server for health sciences · 2023Article
- Aberrant brain entropy in posttraumatic stress disorder comorbid with major depressive disorder during the coronavirus disease 2019 pandemic.Frontiers in psychiatry · 2023Article
- Lower resting brain entropy is associated with stronger task activation and deactivation.NeuroImage · 2022Article
- The relationship between craving and insular morphometry in regular cocaine users: Does sex matter?Addiction biology · 2022Article
- Long-Term Cocaine Self-administration Produces Structural Brain Changes That Correlate With Altered Cognition.Biological psychiatry · 2021Article
- Cocaine addicted rats show reduced neural activity as revealed by manganese-enhanced MRI.Scientific reports · 2020Article
- A Multiscale Deep Learning Method for Quantitative Visualization of Traumatic Hemoperitoneum at CT: Assessment of Feasibility and Comparison with Subjective Categorical Estimation.Radiology. Artificial intelligence · 2020Article
- Acute Alcohol Intake Produces Widespread Decreases in Cortical Resting Signal Variability in Healthy Social Drinkers.Alcoholism, clinical and experimental research · 2020Article
Corrections and comments
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Authors and funding
8 authors at 6 institutions in 2 countries.
Funding
Abstract
Drug addiction is a chronic brain disorder with no proven effective cure. Assessing both structural and functional brain alterations by using multi-modal, rather than purely unimodal imaging techniques, may provide a more comprehensive understanding of the brain mechanisms underlying addiction, which in turn may facilitate future treatment strategies. However, this type of research remains scarce in the literature. We acquired multi-modal magnetic resonance imaging from 20 cocaine-addicted individuals and 19 age-matched controls. Compared with controls, cocaine addicts showed a multi-modal hypo-status with (1) decreased brain tissue volume in the medial and lateral orbitofrontal cortex (OFC); (2) hypo-perfusion in the prefrontal cortex, anterior cingulate cortex, insula, right temporal cortex and dorsolateral prefrontal cortex and (3) reduced irregularity of resting state activity in the OFC and limbic areas, as well as the cingulate, visual and parietal cortices. In the cocaine-addicted brain, larger tissue volume in the medial OFC, anterior cingulate cortex and ventral striatum and smaller insular tissue volume were associated with higher cocaine dependence levels. Decreased perfusion in the amygdala and insula was also correlated with higher cocaine dependence levels. Tissue volume, perfusion, and brain entropy in the insula and prefrontal cortex, all showed a trend of negative correlation with drug craving scores. The three modalities showed voxel-wise correlation in various brain regions, and combining them improved patient versus control brain classification accuracy. These results, for the first time, demonstrate a comprehensive cocaine-dependence and craving-related hypo-status regarding the tissue volume, perfusion and resting brain irregularity in the cocaine-addicted brain.
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